A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors
Abstract Introduction: Natural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and…
allosteric CB1 ligands
Forty sites of TRP channel regulation
Abstract Transient receptor potential (TRP) channels are polymodal molecular sensors that integrate chemical, thermal, mechanical and electrical stimuli and convert…
Structure–Activity Relationship Development Efforts towards Peripherally Selective Analogs of the Cannabinoid Receptor Partial Agonist BAY 59-3074
Abstract Selective modulation of peripheral cannabinoid receptors (CBRs) has potential therapeutic applications in medical conditions, including obesity, diabetes, liver diseases,…
Endocannabinoids in Body Weight Control
Abstract Maintenance of body weight is fundamental to maintain one’s health and to promote longevity. Nevertheless, it appears that the…