Safety of Co-Administered Cannabidiol (CBD) and alcohol: a Phase I study
Abstract Background: This Phase I randomized controlled trial aimed to assess the safety and tolerability of cannabidiol (CBD) and alcohol…
Alcohol use disorder
Long‐Acting Naltrexone Restores Network Connectivity in Subjects With Comorbid Cannabis and Opioid Use Disorder
Abstract Comorbid substance use disorders (SUDs) are common but difficult to study due to the complex, interacting and overlapping mechanisms…
Effect of cannabinol, tetrahydrocannabivarin and cannabidiol on voluntary alcohol consumption
Abstract Aims: Previous studies have demonstrated that the endocannabinoid system plays a significant role in the development of alcohol use…
Factors Associated with Reduced Clinical Response in Adult ADHD: The Role of Alcohol and Cannabis Use Disorders and Autism Spectrum Disorder
Abstract Background: Attention-Deficit/Hyperactivity Disorder (ADHD) in adulthood is frequently associated with complex psychiatric comorbidity, including high rates of Substance Use…
Pharmacological interventions for alcohol use disorder: novel insights from recent clinical trials
Abstract Introduction: 27.1 million adults in the United States have alcohol use disorder (AUD). However, current medications for AUD have…
Effects of cannabidiol in alcohol use disorder patients with and without co‐occurring post‐traumatic stress disorder: Tolerability but no evidence for efficacy in two randomized proof‐of‐concept trials
Abstract Background: Comorbidity between alcohol use disorder (AUD) and post‐traumatic stress disorder (PTSD) exacerbates symptom severity and worsens treatment outcomes.…
Sleep quality and duration following the use and co-use of alcohol and cannabis in the daily life of community adults
Abstract Background: Sleep-promotion is one of the most common reasons people use cannabis. Previous studies, primarily among young adults, suggest…
CBD attenuates amygdala response to negative emotional stimuli in individuals with alcohol use disorder – a randomized controlled trial
Abstract Rationale: Negative affect is a key factor in Alcohol Use Disorder (AUD) associated with craving and relapse risk that…
DSM-5 Criteria for Alcohol and Cannabis Use Disorders: Are Older Adults Less Likely to Endorse Certain Criteria?
Abstract With increasing substance misuse among older adults, we examined the question of whether older adults may be less likely…
A preliminary randomized trial of the safety, tolerability, and clinical effects of hemp-derived cannabidiol in alcohol use disorder
Abstract Introduction: Cannabidiol (CBD) has recently gained attention for its potential therapeutic effects in substance use disorders, including Alcohol Use…