ALKBH5, an m6A demethylase, attenuates tumor growth and inhibits metastasis in papillary thyroid carcinoma
Abstract The significance of ALKBH5 in erasing mRNA methylation in mRNA biogenesis, decay, and translation control has emerged as a…
age-related diseases
The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis
Abstract Although CCL17 has been reported to exert a vital role in many cancers, the related studies in the thyroid…
Comprehensive pan-cancer analysis reveals ENC1 as a promising prognostic biomarker for tumor microenvironment and therapeutic responses
Abstract Accumulating research showed that ENC1 plays a critical role in maintaining the physiological functions. However, little is known about…
Identification of hub modules and therapeutic targets associated with CD8+T-cells in HF and their pan-cancer analysis
Abstract Heart failure (HF) is a terminal condition of multiple cardiovascular disorders. Cancer is a deadly disease worldwide. The relationship…
Cannabidiol effectively prevents oxidative stress and stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) in an animal model of global hypoxia
Abstract Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis sativa. It has therapeutic effects in different paradigms of brain…
iPSC-derived hindbrain organoids to evaluate escitalopram oxalate treatment responses targeting neuropsychiatric symptoms in Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is the most common cause of dementia, and the gradual deterioration of brain function eventually leads…
Cannabidiol improves muscular lipid profile by affecting the expression of fatty acid transporters and inhibiting de novo lipogenesis
Abstract Obesity is one of the principal public health concerns leading to disturbances in glucose and lipid metabolism, which is…
Predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of use
Abstract Cannabis use is a common risk factor for psychoses. But although prevalence of consumption as well as potency of…
Estimates of prevalence, time-trend, and association of smoking in adults living with HIV, HBV, and HCV (NHANES 1999–2018)
Abstract Although the smoking rate of human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) infected…
The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases
Abstract The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence…