Mitochondrial respiratory gene expression is suppressed in many cancers
Abstract The fundamental metabolic decision of a cell, the balance between respiration and fermentation, rests in part on expression of…
Advanced cancer
LNDriver: identifying driver genes by integrating mutation and expression data based on gene-gene interaction network
Abstract Background: Cancer is a complex disease which is characterized by the accumulation of genetic alterations during the patient’s lifetime.…
Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents
Abstract Cancer is the second leading cause of death in the United States with 1.7 million new cases estimated to…
Dissecting the biological relationship between TCGA miRNA and mRNA sequencing data using MMiRNA-Viewer
Abstract Background: MicroRNAs (miRNA) are short nucleotides that interact with their target genes through 3′ untranslated regions (UTRs). The Cancer…
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Abstract Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors…
The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism
Abstract Ki-67 and RepoMan have key roles during mitotic exit. Previously, we showed that Ki-67 organizes the mitotic chromosome periphery…
Investigating cellular network heterogeneity and modularity in cancer: a network entropy and unbalanced motif approach
Abstract Background: Cancer is increasingly recognized as a cellular system phenomenon that is attributed to the accumulation of genetic or…
In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy
Abstract Background: Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) Class I molecules bind to peptide fragments of proteins…
Endocannabinoid system as a regulator of tumor cell malignancy – biological pathways and clinical significance
Abstract The endocannabinoid system (ECS) comprises cannabinoid receptors (CBs), endogenous cannabinoids, and enzymes responsible for their synthesis, transport, and degradation…
Fast dimension reduction and integrative clustering of multi-omics data using low-rank approximation: application to cancer molecular classification
Abstract Background: One major goal of large-scale cancer omics study is to identify molecular subtypes for more accurate cancer diagnoses…