Combining DNA methylation and RNA sequencing data of cancer for supervised knowledge extraction
Abstract Background: In the Next Generation Sequencing (NGS) era a large amount of biological data is being sequenced, analyzed, and…
Advanced cancer
Oncology Clinicians and the Minnesota Medical Cannabis Program: A Survey on Medical Cannabis Practice Patterns, Barriers to Enrollment, and Educational Needs
Abstract Background: Medical cannabis has been available in the State of Minnesota since July 2015 through the Minnesota Medical Cannabis…
lncRNA PVT1 identified as an independent biomarker for prognosis surveillance of solid tumors based on transcriptome data and meta-analysis
Abstract Purpose: Long noncoding RNA PVT1 is dysregulated in some human tumors and has been found to increase the risk…
Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes
Abstract Background: Alternative polyadenylation (APA) results in messenger RNA molecules with different 3′ untranslated regions (3’ UTRs), affecting the molecules’…
Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer
Abstract Cancer represents a significant challenge for humankind, as early diagnosis and treatment are difficult to achieve. To systemically investigate…
Prognostic Value of HMGA2 in Human Cancers: A Meta-Analysis Based on Literatures and TCGA Datasets
Abstract Background: Emerging evidences have shown that the high-mobility group protein A2 (HMGA2) can aberrantly express in human cancers, and…
Discovering mutated driver genes through a robust and sparse co-regularized matrix factorization framework with prior information from mRNA expression patterns and interaction network
Abstract Background: Discovery of mutated driver genes is one of the primary objective for studying tumorigenesis. To discover some relatively…
Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types
Abstract Purpose: The aim of this study was to compare and contrast the expression of all members of the Kallikrein…
The current state and future perspectives of cannabinoids in cancer biology
Abstract To date, cannabinoids have been allowed in the palliative medicine due to their analgesic and antiemetic effects, but increasing…
Discovery and validation of a glioblastoma co-expressed gene module
Abstract Tumors exhibit complex patterns of aberrant gene expression. Using a knowledge-independent, noise-reducing gene co-expression network construction software called KINC,…