Tumor diversity and the trade-off between universal cancer tasks
Abstract Recent advances have enabled powerful methods to sort tumors into prognosis and treatment groups. We are still missing, however,…
Advanced cancer
Identification and ranking of recurrent neo-epitopes in cancer
Abstract Background: Immune escape is one of the hallmarks of cancer and several new treatment approaches attempt to modulate and…
A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types
Abstract RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and translation. Despite their…
The Effects of Dosage-Controlled Cannabis Capsules on Cancer-Related Cachexia and Anorexia Syndrome in Advanced Cancer Patients: Pilot Study
Abstract Background: Cancer-related cachexia and anorexia syndrome (CACS) is a common phenomenon in cancer patients. Cannabis has been suggested to…
The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition
Abstract One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory…
Clustering analysis of microRNA and mRNA expression data from TCGA using maximum edge-weighted matching algorithms
Abstract Background: microRNA (miRNA) is a short RNA (~ 22 nt) that regulates gene expression at the posttranscriptional level. Aberration…
Tumor intrinsic immunity related proteins may be novel tumor suppressors in some types of cancer
Abstract Immune checkpoint blockade therapy (ICBT) can unleash T-cell responses against cancer. However, only a small fraction of patients exhibited…
The heterogeneity and complexity of Cannabis extracts as antitumor agents
Abstract The Cannabis plant contains over 100 phytocannabinoids and hundreds of other components. The biological effects and interplay of these…
Network analysis of aging acceleration reveals systematic properties of 11 types of cancers
Abstract Cancers are known to be associated with accelerated aging, but to date, there has been a paucity of systematic…
Antitumor Cannabinoid Chemotypes: Structural Insights
Abstract Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this…