The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery
Abstract The endocannabinoid system (ECS) is a lipid cell signaling system involved in the physiology and homeostasis of the brain…
Advanced cancer
Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization
Abstract Cannabis sativa contains more than 500 constituents, yet the anticancer properties of the vast majority of cannabis compounds remains…
Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy
Abstract Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose activation is necessary for cell division processes…
Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
Abstract Active telomerase is essential for stem cells and most cancers to maintain telomeres. The enzymatic activity of telomerase is…
Multi-Approach Bioinformatics Analysis of Curated Omics Data Provides a Gene Expression Panorama for Multiple Cancer Types
Abstract Studies describing the expression patterns and biomarkers for the tumoral process increase in number every year. The availability of…
Functional genomics of AP-2α and AP-2γ in cancers: in silico study
Abstract Background: Among all causes of death, cancer is the most prevalent and is only outpaced by cardiovascular diseases. Molecular…
Low-phospholipid-associated cholelithiasis syndrome: Prevalence, clinical features, and comorbidities
Abstract Background & Aims: Low-phospholipid-associated cholelithiasis (LPAC) syndrome, a rare genetic form of intrahepatic cholelithiasis in adults, is still poorly…
Pan-Cancer Multiomics Analysis of TC2N Gene Suggests its Important Role(s) in Tumourigenesis of Many Cancers
Abstract Background: Role of TC2N in carcinogenesis has been largely unfathomed until recently when it was identified as a novel…
A Clinical Genomics-Guided Prioritizing Strategy Enables Selecting Proper Cancer Cell Lines for Biomedical Research
Abstract Selecting appropriate cell lines to represent a disease is crucial for the success of biomedical research, because the usage…
The impact of legalization of access to recreational Cannabis on Canadian medical users with Cancer
Abstract Background: Canada legalized cannabis use for medical purposes in 1999. Legalization of cannabis for recreational purposes in October 2018…