A cross-cohort computational framework to trace tumor tissue-of-origin based on RNA sequencing
Abstract Carcinoma of unknown primary (CUP) is a type of metastatic cancer with tissue-of-origin (TOO) unidentifiable by traditional methods. CUP…
Advanced cancer
Comprehensive analysis of the oncogenic and immunological role of SPON2 in human tumors
Abstract Background: Sapiens spondin-2 (SPON2) is a protein found in the extracellular matrix that plays a role in a number…
Retro-miRs: novel and functional miRNAs originating from mRNA retrotransposition
Abstract Background: Reverse-transcribed gene copies (retrocopies) have emerged as major sources of evolutionary novelty. MicroRNAs (miRNAs) are small and highly…
Prognostic value and immunological role of CSNK1D in human cancers
Abstract CSNK1D, also known as CK1δ, is a crucial gene involved in various biological processes such as cell cycle, transcriptional…
Recapitulation of patient-specific 3D chromatin conformation using machine learning
Abstract Regulatory networks containing enhancer-gene edges define cellular states. Multiple efforts have revealed these networks for reference tissues and cell…
HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth
Abstract 3-Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) is the rate-limiting enzyme for ketone body synthesis, and most current studies focus on mitochondrial…
Comprehensive analysis of PILRΑ’s association with the prognosis, tumor immune infiltration, and immunotherapy in pan-cancer
Abstract Paired immunoglobulin-like type 2 receptor alpha (PILRA) plays a vital role in regulating broad immune responses. However, the roles…
Combining Bulk RNA-seq and scRNA-seq data to identify RNA m5C methyltransferases NSUN1: a rising star as a biomarker for cancer diagnosis, prognosis and therapy
Abstract Background: RNA 5-methylcytosine (m5C) methyltransferases NSUN1 is a member of the NOP2/SUN (NSUN) RNA methyltransferase family. Studies have found…
Algorithmically Reconstructed Molecular Pathways as the New Generation of Prognostic Molecular Biomarkers in Human Solid Cancers
Abstract Individual gene expression and molecular pathway activation profiles were shown to be effective biomarkers in many cancers. Here, we…
A pan-cancer analysis of potassium channel tetramerization domain containing 12 in human cancer
Abstract Abnormal expression of the potassium channel tetramerization domain containing 12 (KCTD12) is closely related to the occurrence and development…