Systematic pan-cancer analysis of the potential tumor diagnosis and prognosis biomarker P4HA3
Abstract Purpose: Prolyl 4-hydroxylase subunit alpha 3 (P4HA3) is implicated in several cancers’ development. However, P4HA3 has not been reported…
adoptive cellular immunotherapy
Distinct roles of ADIPOR1 and ADIPOR2: A pan-cancer analysis
Abstract Introduction: AdipoR1 and AdipoR2 proteins, encoded by ADIPOR1 and ADIPOR2 genes respectively, are the receptors of adiponectin secrected by…
The role of fatty acid desaturase 2 in multiple tumor types revealed by bulk and single-cell transcriptomes
Abstract Background: Previous studies have demonstrated the important role of fatty acid desaturase 2 (FADS2) in governing tumorigenesis and tumor…
Dissecting the role of cancer‐associated fibroblast‐derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single‐cell transcriptomic study
Abstract Introduction: Cancer‐associated fibroblasts (CAFs) are correlated with the immunotherapy response. However, the culprits that link CAFs to immunotherapy resistance…
GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis
Abstract It has been reported that inhibition of GPR65 may be effective for the treatment of certain cancers. Nevertheless, the…
Comprehensive Analysis Reveals Distinct Immunological and Prognostic Characteristics of CD276/B7-H3 in Pan-Cancer
Abstract Background: CD276 (also known as B7-H3), a newly discovered immunoregulatory protein that belongs to the B7 family, is a…
Systematic pan-cancer analysis identifies cGAS as an immunological and prognostic biomarker
Abstract Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causes novel coronavirus disease 2019 (COVID-19), which is characterized…
Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumors
Abstract Background: Mammalian WD-repeat protein 12 (WDR12), a family member of proteins containing repeats of tryptophan-aspartic acid (WD), is a…
Cell death-related biomarker SLC2A1 has a significant role in prognosis prediction and immunotherapy efficacy evaluation in pan-cancer
Abstract Introduction: SLC2A1, a member of the SLC transporter family, is involved in a variety of cell death modalities and…
Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8+ T and NK cells
Abstract Cannabinoid (CB) receptors (CB1 and CB2) are expressed on cancer cells and their expression influences carcinogenesis in various tumor…