Multi-dimensional analysis reveals the potential of PDK4 as a tumor biomarker and target for immunotherapy
Abstract Purpose: To explore the clinical significance of pyruvate dehydrogenase kinase 4 (PDK4) in pan-cancer and its potential as a…
adoptive cellular immunotherapy
Pan-Cancer Analysis of Enhancer-Induced PAN3-AS1 and Experimental Validation as a WFDC13-Promoting Factor in Colon Cancer
Abstract Background: Long non-coding RNAs (lncRNAs) act as epigenetic regulators for tumor hallmarks. This investigation sought to probe the carcinogenic…
Identifying and validating SMARCAL1 as a prognostic and immunotherapy predictive biomarker for NSCLC
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-03980-4. Article type: Research Article Keywords: SMARCAL1, Immunotherapy, Multi-omics,…
E2F transcription factors as multimodal biomarkers for pan-cancer management
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-31042-w. Article type: Research Article Keywords: Pan-cancer, E2F family,…
A comprehensive pan-cancer analysis of the prognostic role and immunotherapy efficacy evaluation of Glyoxalase 1
Abstract Background: Glyoxalase 1 (GLO1), an enzyme responsible for breaking down methylglyoxal (MG), is increasingly recognized as a tumor-promoting factor…
Systematic pan-cancer analysis reveals the prognostic and immunological roles of ectonucleoside triphosphate diphosphohydrolase 6
Abstract BACKGROUND: Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6), a member of the ENTPD family, has been implicated in certain cancers, yet…
Pan-cancer analysis reveals ELFN1 as a novel prognostic biomarker and immunotherapeutic target associated with tumor microenvironment remodeling and promoting malignant phenotypes in colorectal cancer
Abstract Background: Extracellular leucine rich repeat and fibronectin type III domain containing 1 (ELFN1), a transmembrane protein implicated in tumorigenesis…
DHCR7 as a Prognostic and Immunological Biomarker in Human Pan‐Cancer: A Comprehensive Evaluation
Abstract Background: The 7‐Dehydrocholesterol reductase (DHCR7), a critical enzyme catalyzing the final step of the cholesterol biosynthesis pathway, has gained…
Unveiling the significance of ADAM12 through pan-cancer analysis and experimental verification in gastric cancer
Abstract Background: ADAM12, a member of the disintegrin and metalloproteinase family, has been involved in multiple cancers, yet its precise…
Pan-cancer analysis of INHBA indicates its potential prognostic value and correlation with HNSC and LIHC
Abstract Background: INHBA is a member of the TGF-β superfamily and is overexpressed in a variety of cancers and affects…