Repeated administration of cannabidiol decreases splenic lymphocyte subset numbers in rats
Abstract Objective: Cannabidiol (CBD) administration (5 mg/kg) in healthy rats has been shown to significantly decrease lymphocyte subset numbers in…
adolescent rats
Discriminating evidence – use and misuse of the drug-discrimination test in abuse potential assessment of novel CNS drugs
Abstract Nonclinical testing to predict the abuse potential of central nervous system (CNS) drug candidates is a mandatory part of…
Cannabidiol Protects against the Reinstatement of Oxycodone-Induced Conditioned Place Preference in Adolescent Male but Not Female Rats: The Role of MOR and CB1R
Abstract Cannabidiol (CBD), a phytocannabinoid, appeared to satisfy several criteria for a safe approach to preventing drug-taking behavior, including opioids.…
Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2
Abstract Simple Summary: The minimum alveolar concentration of isoflurane (inhaled anesthetic required to prevent movement in 50% of subjects exposed…
CBD Effects on Motor Profile and Neurobiological Indices Related to Glutamatergic Function Induced by Repeated Ketamine Pre-Administration
Abstract Clinical evidence and experimental studies have shown the psychotomimetic properties induced by ketamine. Moreover, acute or chronic ketamine (KET)…
Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol
Abstract Chronic UV radiation causes oxidative stress and inflammation of skin and blood cells. Therefore, in this study, we assessed…
The CB2 Agonist β-Caryophyllene in Male and Female Rats Exposed to a Model of Persistent Inflammatory Pain
Abstract Cannabinoids help in pain treatment through their action on CB1 and CB2 receptors. β-caryophyllene (BCP), an ancient remedy to…
The role of CA1 CB1 receptors on lithium-induced spatial memory impairment in rats
Abstract Lithium, a glycogen synthase kinase-3β (GSK-3β) inhibitor, prevents cannabinoid withdrawal syndrome, but there is limited data exploring the interaction…
Effect of melilotus extract on lung injury by upregulating the expression of cannabinoid CB2 receptors in septic rats
Abstract Background: M. Suaveolens Ledeb has long been used in China to treat inflammatory infectious diseases. Melilotus is extracted from…