Cannabidiol in Humans—The Quest for Therapeutic Targets
Abstract Cannabidiol (CBD), a major phytocannabinoid constituent of cannabis, is attracting growing attention in medicine for its anxiolytic, antipsychotic, antiemetic…
adolescent cannabis use
Pharmacological interventions in the treatment of the acute effects of cannabis: a systematic review of literature
Abstract Background: Cannabis intoxication is related to a number of physical and mental health risks with ensuing social costs. However,…
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications
Abstract Prostate cancer is a global public health problem, and it is the most common cancer in American men and…
Drug-Induced Psychosis: How to Avoid Star Gazing in Schizophrenia Research by Looking at More Obvious Sources of Light
Abstract The prevalent view today is that schizophrenia is a syndrome rather than a specific disease. Liability to schizophrenia is…
Endocannabinoids and Schizophrenia
Abstract The endocannabinoids anandamide and 2-arachydonoylglycerol (2-AG) are lipids naturally derived from membrane precursors which bind cannabinoid receptors (CB1, CB2).…
Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: alone and in combination with ethanol or THC (delta-9-tetrahydrocannabinol)
Abstract Rationale: Typical users of 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”) are polydrug users, combining MDMA with alcohol or cannabis [most active…
Cannabinoid-Induced Hyperemesis: A Conundrum—From Clinical Recognition to Basic Science Mechanisms
Abstract Cannabinoids are used clinically on a subacute basis as prophylactic agonist antiemetics for the prevention of nausea and vomiting…
Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents
Abstract Rationale: Cannabis is the most commonly used illicit drug among pregnant women. Since the endocannabinoid system plays a crucial…
New approaches in the management of spasticity in multiple sclerosis patients: role of cannabinoids
Abstract Cannabinoids such as Cannabis-based medicinal extracts (CBMEs) are increasingly being used in the treatment of spasticity associated with multiple…