The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications
Abstract BTB domain and CNC homolog 1 (BACH1) belongs to the family of basic leucine zipper proteins and is expressed…
adipose stem cells
Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures
Abstract Our knowledge about the consumption of cannabinoids during pregnancy lacks consistent evidence to determine whether it compromises neurodevelopment. Addressing…
Targeting TSPEAR-AS2 suppresses tumor growth and interferon signaling in esophageal cancer
Abstract Dysregulation of long non-coding RNAs (lncRNAs) and interferon signaling contributes to tumorigenesis and progression; however, their crosstalk in tumor…
iPSC-derived hindbrain organoids to evaluate escitalopram oxalate treatment responses targeting neuropsychiatric symptoms in Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is the most common cause of dementia, and the gradual deterioration of brain function eventually leads…
Stem cell index-based RiskScore model for predicting prognosis in thyroid cancer and experimental verification
Abstract Objective: An mRNA expression-based stemness index (mRNAsi) has been developed to characterize cancer stemness. However, the predictive value of…
Hemp Seed Oil Inhibits the Adipogenicity of the Differentiation-Induced Human Mesenchymal Stem Cells through Suppressing the Cannabinoid Type 1 (CB1)
Abstract Central and peripheral mechanisms of the endocannabinoid system (ECS) favor energy intake and storage. The ECS, especially cannabidiol (CBD)…
Recent Advances in Management of Neuropathic, Nociceptive, and Chronic Pain: A Narrative Review with Focus on Nanomedicine, Gene Therapy, Stem Cell Therapy, and Newer Therapeutic Options
Abstract Purpose of Review: This manuscript summarizes novel clinical and interventional approaches in the management of chronic, nociceptive, and neuropathic…
Determinants of astrocytic pathology in stem cell models of primary tauopathies
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-023-01655-1. Article type: Research Article Keywords: Astrocytes, Stem cells,…
Determinants of Astrocytic Pathology in Stem Cell Models of Primary Tauopathies
Abstract Astrocytic tau aggregates are seen in several primary and secondary tauopathies, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD),…
The Implications of Cannabinoid-Induced Metabolic Dysregulation for Cellular Differentiation and Growth
Abstract The endocannabinoid system (ECS) governs and coordinates several physiological processes through an integrated signaling network, which is responsible for…