Antiseizure Medications: Advancements, Challenges, and Prospects in Drug Development
Abstract Epilepsy is a neurological disorder affecting millions of people worldwide. Antiseizure medications (ASM) remain a critical therapeutic intervention for…
adenosine and serotonin neurotransmission
Audiogenic epileptic DBA/2 mice strain as a model of genetic reflex seizures and SUDEP
Abstract Epilepsy is a chronic neurological disease characterized by abnormal brain activity, which results in repeated spontaneous seizures. Sudden unexpected…
Identification of BiP as a CB1 Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain
Abstract Cannabinoids, the bioactive constituents of cannabis, exert a wide array of effects on the brain by engaging Type 1…
Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1
Abstract Existing treatments against drug addiction are often ineffective due to the complexity of the networks of protein-drug and protein-protein…