Demographic features, health status, and behavioral changes associated with cannabidiol use in the Dog Aging Project
Abstract Introduction: In recent years, there has been an increase in access to and interest in cannabidiol (CBD) and hemp…
adaptive behavior
Hexahydrocannabinol: pharmacokinetics, systemic toxicity, and acute behavioral effects in Wistar rats
Abstract Background: Hexahydrocannabinol (HHC) is a new psychoactive substance known for its mind-altering effects and temporary legal status. It is…
Evaluation of Cannabidiol Oil’s Effects on Sedation, Behavioral Responses to Handling, and Nociceptive Thresholds in Healthy Cats
Abstract This study aimed to provide an initial assessment of the effects of cannabidiol (CBD) oil on sedation, compliance during…
Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-82353-3. Article type: Research Article Keywords: Cannabinoid, Motor, Sensory,…
Functional Adaptation in the Brain Habenulo–Mesencephalic Pathway During Cannabinoid Withdrawal
Abstract The mesolimbic reward system originating from dopamine neurons in the ventral tegmental area (VTA) of the midbrain shows a…
Behavioral effects of two cannabidiol and cannabigerol-rich formulas on mice
Abstract Cannabis sativa L. produces more than 100 specific bioactive compounds, known as cannabinoids. The major non-psychotropic Cannabis constituent is…
Fetal Cannabinoid Syndrome: Behavioral and Brain Alterations of the Offspring Exposed to Dronabinol during Gestation and Lactation
Abstract This study establishes a fetal cannabinoid syndrome model to evaluate the effects of high doses of dronabinol (synthetic THC)…
Timeframe Analysis of Novel Synthetic Cannabinoids Effects: A Study on Behavioral Response and Endogenous Cannabinoids Disruption
Abstract This study investigates the impact of SCs consumption by assessing the effects of three novel synthetic cannabinoids (SCs); MDMB-CHMINACA,…
A preclinical model of THC edibles that produces high-dose cannabimimetic responses
Abstract No preclinical experimental approach enables the study of voluntary oral consumption of high-concentration Δ9-tetrahydrocannabinol (THC) and its intoxicating effects,…
Cannabidiol (Epidyolex®) for severe behavioral manifestations in patients with tuberous sclerosis complex, mucopolysaccharidosis type III and fragile X syndrome: protocol for a series of randomized, placebo-controlled N-of-1 trials
Abstract Background: Many rare genetic neurodevelopmental disorders (RGNDs) are characterized by intellectual disability (ID), severe cognitive and behavioral impairments, potentially…