The endocannabinoid system as a therapeutic target in intestinal fibrosis
Abstract Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases, often leading to strictures that require endoscopic…
acute inflammation
The effects of cannabidiol on nitric oxide synthases: a narrative review on therapeutic implications for inflammation and oxidative stress in health and disease
Abstract Cannabidiol (CBD), a non-psychoactive compound from Cannabis sativa, shows promise as a therapeutic agent for conditions associated with inflammation…
Considering the Effects of Cannabinoids and Exercise on the Brain: A Narrative Review
Abstract Recently, there has been rising interest in the use of cannabis and its derivatives as therapeutic tools to support…
Cannabinoid Receptor 2 (CB2) in Macrophages: A Promising Clinical Target for Immune Disorders
Abstract Macrophages are essential for immune homeostasis, playing crucial roles in immune responses from initiation to resolution. They trigger acute…
Microglial activation is inhibited by selective anti-seizure medications
Abstract Objective: To investigate the anti-inflammatory properties of anti-seizure medications (ASMs) administered to patients with drug-resistant epilepsy (DRE) and the…
Biotechnological potential of Cannabis sativa adventitious roots for producing immunomodulatory and anti-inflammatory bioactive compounds
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-16130-1. Article type: Research Article Keywords: Adventitious roots, Dendritic…
Cannabidiol Enhances the Therapeutic Efficacy of Olsalazine and Cyclosporine in a Murine Model of Colitis
Abstract Current therapies for inflammatory bowel disease (IBD), such as olsalazine and cyclosporine, often exhibit limited long-term efficacy and are…
Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects
Abstract Palmitoylethanolamide (PEA) has attracted increasing attention from researchers as an endogenous lipid mediator. It exhibits a unique mechanism of…
Loganic acid ameliorates diabetic cardiomyopathy via suppressing TLR4/p38 MAPK signaling-mediated oxidative stress and inflammation
Abstract Diabetic cardiomyopathy (DCM), a life-threatening cardiovascular complication of diabetes, manifested as progressive cardiac dysfunction mediated through oxidative stress, inflammation,…
Hybrid Cannabis sativa L. inflorescences exert an anti-inflammatory effect through the modulation of MAPK/NF-κB/NLRP3 inflammasome and JAK1/STAT6 pathway in HaCaT cells
Abstract Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied by severe itching. Reducing mediators of skin inflammation…