Abstract Somatic copy number alterations (CNAs) are a hallmark of cancer, but their role in tumorigenesis and clinical relevance remain…
Abstract Delta‐9‐tetrahydrocannabinol (Δ9‐THC) is a naturally occurring psychoactive compound derived from the hemp plant Cannabis sativa. In 2015, EFSA established…
Abstract FOXO transcription factors are critical regulators of cell homeostasis and steer cell death, differentiation and longevity in mammalian cells.…
Abstract Background: The impact of increasing non-medical cannabis use on vulnerability to develop opioid use disorders has received considerable attention,…
Abstract Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling…
Abstract Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic…
Abstract HnRNP A1 regulates many alternative splicing events by the recognition of splicing silencer elements. Here, we provide the solution…
Abstract Site-specific histone ubiquitylation plays a central role in orchestrating the response to DNA double-strand breaks (DSBs). DSBs elicit a…
Abstract The fundamental metabolic decision of a cell, the balance between respiration and fermentation, rests in part on expression of…
Abstract Ki-67 and RepoMan have key roles during mitotic exit. Previously, we showed that Ki-67 organizes the mitotic chromosome periphery…