Role of E3 Ubiquitin Ligases in Oligodendrocyte Health and Disease
Abstract Protein ubiquitination is a type of posttranslational modification that occurs in all cells to regulate numerous biological processes. Ubiquitination…
Activated microglia
Oromucosal Administration of a Cannabidiol‐Enriched Cannabis sp. Extract for 2 Weeks Moderately Reduces Cold Hyperalgesia in Rats With Neuropathic Pain
Abstract Background: Chronic neuropathic pain (CNP) involves complex interactions between resident and peripheral immune cells, as well as modulation of…
Cannabidiol and other non-psychotropic cannabinoids from Cannabis sativa as therapeutics for microglial-mediated neuroinflammation and neurodegeneration
Abstract Non-psychotropic phytocannabinoids produced by Cannabis sativa, including cannabidiol, cannabigerol, cannabichromene and their varin and acidic analogs, are emerging as…
Anti-Neuroinflammatory Cannabinoid Acids as a New Therapeutic Approach for Multiple Sclerosis
Abstract Neuroinflammation is a hallmark of multiple sclerosis (MS). MS is marked by glial cell activation, autoreactive T cells, and…
Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia
Abstract Graphical Abstract: Created in BioRender. Espinoza, C. (2025) https://BioRender.com/mxfla3i Supplementary Information: The online version contains supplementary material available at…
Microglial activation is inhibited by selective anti-seizure medications
Abstract Objective: To investigate the anti-inflammatory properties of anti-seizure medications (ASMs) administered to patients with drug-resistant epilepsy (DRE) and the…
The Effects of Cannabinoids on Ischemic Stroke-Associated Neuroinflammation: A Systematic Review
Abstract Graphical Abstract: Article type: Review Article Keywords: Stroke, Inflammation, Cannabinoids, Neuroinflammation, Neuroprotection, Astrocytes, Microglia, Blood–Brain Barrier Authors: Eman A.…
Neuroprotective and Anti-Inflammatory Effects of Dimethyl Fumarate, Monomethyl Fumarate, and Cannabidiol in Neurons and Microglia
Abstract Dimethyl fumarate (DMF) is an immunomodulatory treatment for multiple sclerosis (MS) that can cross the blood–brain barrier, presenting neuroprotective…
FDA-approved cannabidiol [Epidiolex®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis
Abstract Background: Chronic Gulf War Illness (GWI) is characterized by cognitive and mood impairments, as well as persistent neuroinflammation and…
Effects of cannabidiol, with and without ∆9-tetrahydrocannabinol, on anxiety-like behavior following alcohol withdrawal in mice
Abstract Introduction: Alcohol use disorder (AUD) is commonly associated with anxiety disorders and enhanced stress-sensitivity; symptoms that can worsen during…