Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity
Abstract Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and could produce an “entourage effect” whereby…
abdominal pain
Systematic review and meta-analysis of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators tested for antinociceptive effects in animal models of injury-related or pathological persistent pain
Abstract Supplemental Digital Content is Available in the Text. Article type: Research Article Keywords: Cannabinoids, Cannabis-based medicine, Endocannabinoid system modulator,…
The Therapeutic Potential and Usage Patterns of Cannabinoids in People with Spinal Cord Injuries: A Systematic Review
Abstract Background: People with spinal cord injuries (SCI) commonly experience pain and spasticity; limitations of current treatments have generated interest…
SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB1 receptors
Abstract Background and Purpose: Src homology 3‐domain growth factor receptor‐bound 2‐like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid CB1…
The Endocannabinoid System Contributes to Electroacupuncture Analgesia
Abstract The extensive involvement of the endocannabinoid system (ECS) in vital physiological and cognitive processes of the human body has…
High and Mighty? Cannabinoids and the microbiome in pain
Abstract In this review, we will focus on the potential role of the endogenous cannabinoids in modulating microbiota-driven changes in…
The endocannabinoid system – current implications for drug development
Abstract In this review, the state of the art for compounds affecting the endocannabinoid (eCB) system is described with a…
Considerations for Cannabis Use to Treat Pain in Sickle Cell Disease
Abstract Pain in Sickle Cell Disease (SCD) is a major comorbidity and unique with acute pain due to recurrent and…
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action
Abstract Cannabis has a long history of medical use. Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and…
Cannabis in Gastroenterology: Watch Your Head! A Review of Use in Inflammatory Bowel Disease, Functional Gut Disorders, and Gut-Related Adverse Effects
Abstract Purpose of review: To review recent clinical evidence surrounding the use of cannabinoids and cannabis in gastrointestinal diseases, particularly…