Profiling bile acid composition in bile from mice of different ages and sexes
Abstract Introduction: Bile BA profiling is important for understanding the pathogenetic mechanisms underlying gallbladder and gastrointestinal diseases. Until now, bile…
212-2 self-administration mouse model
Targeting Src tyrosine kinase to enhance radioiodide uptake in breast cancer
Abstract Sodium iodide symporter (NIS) expression in breast cancer renders radioiodide (RAI) a promising treatment modality. However, insufficient functional NIS…
Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats
Abstract Rationale: Animal models of cannabinoid self-administration are critical for advancing our understanding of the neurobiology of cannabis use and…
Hexahydrocannabinol: pharmacokinetics, systemic toxicity, and acute behavioral effects in Wistar rats
Abstract Background: Hexahydrocannabinol (HHC) is a new psychoactive substance known for its mind-altering effects and temporary legal status. It is…
Acute and subacute cardiovascular effects of synthetic cannabinoid JWH-018 in rat
Abstract Purpose: This study investigates the cardiovascular effects of the synthetic cannabinoid naphthalene-1-yl-(1-pentylindole-3-yl)methanone (JWH-018) in rats. The research aims to…
Characterizing the Role of Endocannabinoid Receptor Cnr1 in Mouse Ovarian Granulosa Cells
Abstract The endocannabinoid receptors Cnr1 and Cnr2 have been found in reproductive organs such as the oviduct and uterus. These…
Region-Specific Impact of Repeated Synthetic Cannabinoid Exposure and Withdrawal on Endocannabinoid Signaling, Gliosis, and Inflammatory Markers in the Prefrontal Cortex and Hippocampus
Abstract Synthetic cannabinoid use raises concerns about its neuroinflammatory effects, including molecular adaptations of the endocannabinoid system (ECS) in the…
Chronic exposure to a synthetic cannabinoid improves cognition and increases locomotor activity in Tg4-42 Alzheimer’s disease mice
Abstract Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and behavior impairments. Despite recent approvals of…
Construction of an anaplastic thyroid cancer stratification signature to guide immune therapy selection and validation of the pivotal gene HLF through in vitro experiments
Abstract Introduction: While most thyroid cancer patients have a favorable prognosis, anaplastic thyroid carcinoma (ATC) remains a particularly aggressive form…
Impact of Long-Term Cannabidiol (CBD) Treatment on Mouse Kidney Transcriptome
Abstract Background: Cannabidiol, which is one of the main cannabinoids present in Cannabis sativa plants, has been shown to have…