Abstract Background: Most substance users are polysubstance users; however, little is known about how the combined use of different drugs…
Abstract Rationale: Animal models of cannabinoid self-administration are critical for advancing our understanding of the neurobiology of cannabis use and…
Abstract Background: Hexahydrocannabinol (HHC) is a new psychoactive substance known for its mind-altering effects and temporary legal status. It is…
Abstract Purpose: This study investigates the cardiovascular effects of the synthetic cannabinoid naphthalene-1-yl-(1-pentylindole-3-yl)methanone (JWH-018) in rats. The research aims to…
Abstract The endocannabinoid receptors Cnr1 and Cnr2 have been found in reproductive organs such as the oviduct and uterus. These…
Abstract Synthetic cannabinoid use raises concerns about its neuroinflammatory effects, including molecular adaptations of the endocannabinoid system (ECS) in the…
Abstract Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and behavior impairments. Despite recent approvals of…
Abstract Background: Cannabidiol, which is one of the main cannabinoids present in Cannabis sativa plants, has been shown to have…
Abstract We used our mouse papillomavirus (MmuPV1) model to test the hypothesis that two primary psychoactive ingredients of marijuana, Δ9-tetrahydrocannabinol…
Abstract Background: Defective mitochondria and aberrant brain mitochondrial bioenergetics are consistent features in syndromic intellectual disability disorders, such as Rett…