RNA Methylation in Cancer Metabolism: from Mechanisms to Therapeutic Opportunities
Abstract One of the most important changes in the transformation of normal cells into tumor cells is metabolism. In order…
Science Article
Pan-Cancer Analysis of Enhancer-Induced PAN3-AS1 and Experimental Validation as a WFDC13-Promoting Factor in Colon Cancer
Abstract Background: Long non-coding RNAs (lncRNAs) act as epigenetic regulators for tumor hallmarks. This investigation sought to probe the carcinogenic…
Single-cell and spatial transcriptomics reveal P4HA2-mediated radiotherapy resistance mechanisms in breast cancer
Abstract Background: Radiotherapy resistance in breast cancer remains a major clinical challenge. The key molecular determinants and cellular populations driving…
Enhancing cancer susceptibility to disulfidptosis by inducing cell cycle arrest and impairing DNA repair
Abstract Disulfidptosis—a regulated cell death caused by disulfide stress under glucose starvation and high SLC7A11—offers a potential cancer vulnerability, but…
IGF2BP2 Drives Thyroid Cancer Dedifferentiation Through m6A-Dependent STAT1 mRNA Destabilization
Abstract Thyroid cancer is the most common endocrine malignancy globally. While papillary thyroid carcinoma (PTC) typically exhibits favorable prognosis, a…
Integrated Pan-Cancer Profiling and Breast Cancer Validation Identify BEND3 as a Potential Prognostic and Immune Biomarker
Abstract Purpose: BEND3 is implicated in various physiological processes, including chromatin regulation, cell cycle regulation, etc.; nonetheless, its function in…
Combination of red and UV-A light enhances hemp (Cannabis sativa L.) inflorescence yield and cannabinoid content
Abstract Light spectrum plays a crucial role in regulating the growth of hemp (Cannabis sativa L.) plants and the biosynthesis…
Computational Identification of Potent Multitarget Natural Ligands for Alzheimer’s Disease Therapeutics
Abstract Alzheimer’s disease (AD), a complex neurodegenerative disorder, urgently necessitates a multitarget therapeutic approach. This study presents a novel in…
Identifying and validating SMARCAL1 as a prognostic and immunotherapy predictive biomarker for NSCLC
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-03980-4. Article type: Research Article Keywords: SMARCAL1, Immunotherapy, Multi-omics,…
Psychological distress, self-efficacy, and academic advising among Saudi nursing students during academic reform: a mixed-methods study
Abstract Background: Changes in academic structure—such as the implementation of a trimester system—can impose considerable psychological strain on students. In…