Methamphetamine Use in People Living with HIV: Clinical, Neurocognitive, and Blood Biomarker Profiles
Abstract Background: Methamphetamine (MA) use in people living with HIV (PLWH) has been linked to neurocognitive and behavioral dysregulation. We…
Science Article
Reducing severe breathlessness with dronabinol in the group of patients with severe and very severe chronic obstructive pulmonary disease (BONG): a randomised, double-blinded, placebo-controlled, crossover study in an outpatient clinic in Denmark – a study protocol
Abstract Introduction: Cannabis-based medicine may alleviate breathlessness. This study will investigate whether dronabinol, a synthetic form of Δ9-tetrahydrocannabinol (Δ9-THC), reduces…
Delta‐9‐Tetrahydrocannabinol (THC) Before Bedtime: Feasibility and Mechanistic Pilot Study on Sleep and Cardiac Autonomic Activity
Abstract Disordered sleep is a common reason individuals report using cannabis, yet the physiological effects of Δ9‐tetrahydrocannabinol (Δ9‐THC) on sleep…
Pharmacogenetic association study of cannabis use in chronic pain
Abstract Background: Pain is one of the leading causes of disability worldwide. Despite the various pharmacological treatments available, patients with…
Is Cannabis Dependence Associated with Postoperative Infections in Hand and Wrist Surgeries?
Abstract Purpose: Recreational cannabis use has been increasing alongside broader legalization efforts worldwide. Despite this trend, relatively little data exist…
Recent Trends in Cannabis Use in Adults Ages 60 Years and Older
Abstract This narrative review highlights the growing population of older adults (OA) who use cannabis and health considerations of cannabis…
Isolation and Functional Characterization of Carob-Derived Nanovesicles Reveals Anti-Inflammatory and Regenerative Potential
Abstract Plant-derived nanovesicles (PDNVs) are increasingly recognized as mediators of intercellular communication in plants, where they play roles in defense,…
Investigating the psychedelic hypothesis of kykeon, the sacred elixir of the Eleusinian Mysteries
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-39568-3. Article type: Research Article Keywords: Psychedelic, Eleusinian Mysteries,…
Integrated Computational Investigation of Cannabis sativa Phytoconstituents as Putative Multi-Target Inhibitors in Skin Cancer: A Molecular Docking, Dynamics, and ADMET Profiling Study
Abstract Background: Skin cancer progression is driven by the dysregulation of key oncogenic signaling pathways, including EGFR, BRAF V600E, and…
Investigating the Synergistic Effect of the Cannabis Extract PHEC-66 and Chemotherapeutic Agents on Human Melanoma Cells
Abstract Melanoma is a malignant neoplasm that originates from melanocytes. It continues to pose a significant challenge in oncology due…