Point estimation for adaptive trial designs II: Practical considerations and guidance
Abstract In adaptive clinical trials, the conventional end‐of‐trial point estimate of a treatment effect is prone to bias, that is,…
Science Article
Association between serum Chlamydia trachomatis antibody levels and infertility among reproductive-aged women in the U.S.
Abstract Introduction: Chlamydia trachomatis infection, the most prevalent sexually transmitted bacterial infection worldwide, is a significant cause of infertility. Many…
A Case of a Patient With Cannabis Hyperemesis Syndrome Along With Recurrent Nephrolithiasis
Abstract Cannabis hyperemesis syndrome (CHS) is a condition characterized by cyclic vomiting and abdominal pain in chronic cannabis users. It…
Use of Selective Alternative Therapies for Treatment of OCD
Abstract About 40% of the people with the obsessive-compulsive-disorder do not experience the desired outcome after the existing treatment, and…
Cannabinoids and Multiple Sclerosis: A Critical Analysis of Therapeutic Potentials and Safety Concerns
Abstract Multiple sclerosis (MS) is a complicated condition in which the immune system attacks myelinated axons in the central nervous…
Continuous-Flow Synthesis of Δ9-Tetrahydrocannabinol and Δ8-Tetrahydrocannabinol from Cannabidiol
Abstract A challenging step in the preparation of tetrahydrocannabinol analogs is an acid-catalyzed intramolecular cyclization of the cannabidiol precursor. This…
Alginate-Based Materials Loaded with Nanoparticles in Wound Healing
Abstract Alginate is a naturally derived polysaccharide widely applied in drug delivery, as well as regenerative medicine, tissue engineering and…
Glandular trichome development, morphology, and maturation are influenced by plant age and genotype in high THC-containing cannabis (Cannabis sativa L.) inflorescences
Abstract Background: Glandular capitate trichomes which form on bract tissues of female inflorescences of high THC-containing Cannabis sativa L. plants…
Clinical Evaluation of Sleep Disorders in Parkinson’s Disease
Abstract The paradigm of the framing of Parkinson’s disease (PD) has undergone significant revision in recent years, making this neurodegenerative…
“You Almost Feel Out of Touch [For Saying] … ‘Oh, and by the way, Stop Smoking.’” A Qualitative Exploration of Provider Perspectives About Discussing Tobacco and Cannabis Use With 18-24-Year-Old Young Adults With HIV
Abstract Background: Youth with HIV (YWH) aged 18–24 are overburdened by tobacco, with half also using cannabis recreationally. Increasing tobacco…