Synthetic and Medicinal Chemistry Approaches Toward WEE1 Kinase Inhibitors and Its Degraders
Abstract WEE1 is a checkpoint kinase critical for mitotic events, especially in cell maturation and DNA repair. Most cancer cells’…
Science Article
A Narrative Review of Alternative Symptomatic Treatments for Herpes Simplex Virus
Abstract Herpes simplex virus-1 (HSV-1) and -2 (HSV-2) are large, spherically shaped, double-stranded DNA viruses that coevolved with Homo sapiens…
Cannabis for the Treatment of Fibromyalgia: A Systematic Review
Abstract Fibromyalgia is a common disease syndrome characterized by chronic pain and fatigue in conjunction with cognitive dysfunction such as…
Uso de sustancias psicoactivas como tratamiento de la psicosis
Abstract Introducción.: Los trastornos psicóticos se consideran problemas crónicos de salud mental. Aunque se ha demostrado que estos trastornos pueden…
Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application
Abstract The use of bioresourced packaging materials is an interesting solution for ecological issues. This work aimed to develop novel…
Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders
Abstract During the last decade, substance use disorders (SUDs) have been increasingly recognized as neuroinflammation-related brain diseases. Various types of…
The endogenous cannabinoid system modulates male sexual behavior expression
Abstract The endocannabinoid system (ECS) plays a key neuromodulatory role in the brain. Main features of endocannabinoids (eCBs) are that…
The Role of the Endocannabinoid System in Binge Eating Disorder
Abstract Eating disorders are multifactorial disorders that involve maladaptive feeding behaviors. Binge eating disorder (BED), the most prevalent of these…
Shift handover quality in Saudi critical care units: determinants from nurses’ perspectives
Abstract Background: Nurses’ effective handover communication is vital for patient safety and quality of care. Few studies have empirically tested…
The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer’s Disease in AppNL-G-F Knock-In Mice
Abstract Simple Summary: Alzheimer’s disease (AD) is a complex, multifactorial disease where numerous components, such as environment, lifestyle, comorbidities, and…