Exploring The Contours: Navigating Cannabis Use Among Older Adults
Abstract Cannabis has been employed medicinally throughout history, with recent renewed interest for use due to media awareness and medical…
Science Article
The role of silicon in drug discovery: a review
Abstract This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are often regarded as…
Isolation and characterization of synthesis intermediates and side products in hexahydrocannabiphorol
Abstract After the Swiss ban of hexahydrocannabinol (HHC) in March 2023, other semisynthetic dibenzopyran cannabinoids emerged on the Swiss gray…
Cannabidiol Alleviates Oral Mucositis by Inhibiting PI3K/Akt/NF-κB-Mediated Pyroptosis
Abstract Background: Cannabidiol (CBD), extracted from Cannabis sativa, has anticancer, anti-inflammation, and analgesic effects. Nevertheless, its therapeutic effect and the…
Endocannabinoid levels in plasma and neurotransmitters in the brain: a preliminary report on patients with a psychotic disorder and healthy individuals
Abstract Background: Interactions between the endocannabinoid system (ECS) and neurotransmitter systems might mediate the risk of developing a schizophrenia spectrum…
Effects of Cannabis on Glutamatergic Neurotransmission: The Interplay between Cannabinoids and Glutamate
Abstract There has been a significant increase in the consumption of cannabis for both recreational and medicinal purposes in recent…
In the weeds: A comprehensive review of cannabis; its chemical complexity, biosynthesis, and healing abilities
Abstract For millennia, various cultures have utilized cannabis for food, textile fiber, ethno-medicines, and pharmacotherapy, owing to its medicinal potential…
Protocol for a pragmatic trial of Cannabidiol (CBD) to improve chronic pain symptoms among United States Veterans
Abstract Background: Chronic pain affects over 100 million Americans, with a disproportionately high number being Veterans. Chronic pain is often…
Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
Abstract Metabotropic glutamate receptors (mGluRs) are part of the G protein-coupled receptors (GPCRs) family. They are coupled to Gαq (group…
Natural Health Products for Symptomatic Relief of Parkinson’s Disease: Prevalence, Interest, and Awareness
Abstract Background: Natural health products have emerged as a potential symptomatic therapeutic approach for people with Parkinson’s disease (PD). Objective:…