Trends in burden and mortality of congenital birth defects in G20 countries (1990–2021) and predictions for 2022–2040
Abstract Objectives: Congenital birth defects (CBDs) rank among the top five causes of death in children under the age of…
Science Article
Impact of clinical factors on the diagnostic performance of diffuse optical spectroscopic imaging for breast cancer
Abstract Due to insufficient sensitivity of mammography in dense breasts, ultrasonography and MRI have been incorporated into breast screening, despite…
Boosting Biocatalytic Efficiency: Engineering of Chitinase Chit33 with Chitin and Cellulose Binding Domains for Sustainable Chitin Conversion
Abstract Endochitinase Chit33 has shown great potential in converting chitin, a recalcitrant waste, into bioactive chitooligosaccharides (COS). This study evaluates…
Interplay between lipid profiles, thyroid function, and gallstone disease: A clinical perspective
Abstract Background: New research points to a complicated relationship between gallstone disease (GSD), thyroid function, and lipid profiles. To better…
Microwave-Assisted Extraction of Hemp Seed Oil: Process Optimization for Enhancing Oil Yield and Bioactive Compound Extractability
Abstract Hemp seed oil is a valuable source of unsaturated fatty acids. However, its high degree of unsaturation makes it…
Medicinal plants trade in Harare’s urban markets: diversity, conservation status, and economic significance
Abstract Background: Urban markets serve as crucial centres for trading traditional medicinal plants, yet there is limited research on the…
Clinical and financial impact of a ‘difficult’ laparoscopic cholecystectomy
Abstract Background: Difficult intra‐operative findings during laparoscopic cholecystectomy (LC) may lead to poor clinical outcomes. This study aimed to compare…
Understanding the role of oxylipins in Cannabis to enhance cannabinoid production
Abstract Phytocannabinoids are medically important specialized defense compounds that are sparsely distributed among plants, yet Cannabis sativa can synthesize unprecedented…
Cannabidiol as a novel therapeutic agent in breast cancer: evidence from literature
Abstract Background: Breast cancer is one of the most prevalent cancers worldwide, posing significant challenges due to its heterogeneity and…
The mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy
Abstract Transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) play key roles in cancers through transcriptional…