Natural protection against oxidative stress in human skin melanocytes
Abstract Human skin plays a crucial role in protecting the body against environmental stressors. The skin cells involved in photoprotection…
Science Article
Cannabidiol dampens propagation of hippocampal hyperactivity and differentially modulates feedforward and feedback inhibition
Abstract Cannabidiol (CBD) decreases seizures in patients with severe pediatric-onset epilepsies including Dravet, Lennox-Gastaut, and Tuberous Sclerosis syndromes. However, the…
Cannabis use is associated with changes in psychological and functional well-being during young adulthood: evidence from self-reports and hair analyses
Abstract Background: Cannabis use in young adulthood is common, yet few studies have explored how it predicts changes in psychopathology…
For those with schizophrenia, does cannabidiol make cannabis use safer?
Keywords: Schizophrenia, Drug development Authors: Anya K. Bershad ⚬ Affiliations: https://ror.org/046rm7j60grid.19006.3e0000 0000 9632 6718Department of Psychiatry and Biobehavioral Sciences, Jane…
Bubble Perfusion Brain Slice Culture with Single-Droplet Stimulus Delivery in a 3D Printed Microfluidic Device
Abstract Ex vivo tissue culture can model tissue physiology under well-controlled conditions and is especially promising for understanding the complex…
Cannabidiol prevents cognitive and social deficits in a male rat model of Alzheimer’s disease through CB1 activation and inflammation modulation
Abstract Cognitive decline is a hallmark of Alzheimer’s disease (AD). Cannabidiol (CBD), a non-intoxicating phytocannabinoid with immunomodulatory properties, shows promise…
Tū Whakaruruhau: the evaluation of treatment outcomes for methamphetamine dependence in Aotearoa, New Zealand – study protocol for a prospective longitudinal cohort study and longitudinal qualitative study
Abstract Background: Methamphetamine is the second most used illicit drug in Aotearoa New Zealand, after cannabis. Regular and heavy users…
Unraveling the Enigma of Cannabinoid Hyperemesis Syndrome: A Narrative Review of Diagnosis and Management
Abstract Cannabinoid hyperemesis syndrome (CHS) is a serious condition primarily seen in chronic cannabis users, characterized by persistent cycles of…
Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory deficits in Huntington’s disease models
Abstract Background: Dysregulation of the endocannabinoid system (eCBS) and the loss of CB1 receptors (CB1R) in the basal ganglia are…
Hexahydrocannabinol and Hexahydrocannabiphorol Poisonings: Data From the Czech Toxicology Information Centre and Effects of Legislative Changes
Abstract Hexahydrocannabinol, a hydrogenated derivative of cannabinol, first came to the Czech Toxicological Information Centre (TIC) following reports of poisonings…