Learning and actioning general principles of cancer cell drug sensitivity
Abstract High-throughput screening of drug sensitivity of cancer cell lines (CCLs) holds the potential to unlock anti-tumor therapies. In this…
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Comprehensive pan-cancer analysis of ENOPH1 in human tumors
Abstract Background: ENOPH1 (Enolase-phosphatase 1), a member of the HAD-like hydrolase superfamily, has been linked to a range of physiological…
Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma
Abstract BACKGROUND: Although transmembrane protein 106C (TMEM106C) has been elucidated to be overexpressed in cancers, its underlying mechanisms have not…
p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10555-025-10250-w. Article type: Review Article Keywords: P62/SQSTM1, Modular structures,…
In Vitro Antiplasmodial Activity and Chemical Composition of Combretum aculeatum, a Medicinal Plant From Niger
Abstract Malaria remains a significant public health challenge in Niger, accounting for 5.6% of global malaria‐related deaths. Local medicinal plants…
Optimizing Electrochemical Performance: A Study of Aqueous Electrolytes with Hemp-Derived Activated Carbon for Supercapacitors
Abstract This work investigates the synthesis and electrochemical performance of hemp-derived activated carbon (HAC) for supercapacitor electrode applications. HAC was…
Efficacy of cannabidiol alone or in combination with Δ‐9‐tetrahydrocannabinol for the management of substance use disorders: An umbrella review of the evidence
Abstract Background and Aims: Substance use disorders (SUD) lead to a high burden of disease, yet treatment options are limited.…
Pan-cancer and multi-omics analysis: NDUFA1 is a potential therapeutic target and prognostic marker for esophageal cancer
Abstract Objectives: The study examined the NDUFA1 expression and its prognostic value in pan-cancer, especially in esophageal cancer (ESCA). Its…
Comprehensive analysis of LRRC42 as a potential biomarker and key cellular processes in cancer development
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-88467-6. Article type: Research Article Keywords: LRRC42, Progression biomarker,…
Tendomodulin in pan-cancer analysis: exploring its impact on immune modulation and uncovering functional insights in colorectal cancer
Abstract Background: Tendomodulin (TNMD) is pivotal in various malignancies, including colorectal cancer (CRC). However, its comprehensive impact across cancers, particularly…