Shared Mechanisms of Alcohol and Other Drugs
Abstract Identifying the changes that occur in the brain as a result of alcohol and other drug (AOD) use is…
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The Consumption of Khat and Other Drugs in Somali Combatants: A Cross-Sectional Study
Abstract Background: For more than a decade, most parts of Somalia have not been under the control of any type…
Historical and cultural aspects of man’s relationship with addictive drugs
Abstract Our taste for addictive psychoactive substances is attested to in the earliest human records. Historically, psychoactive substances have been…
Cannabinoids in health and disease
Abstract Cannabis sativa L. preparations have been used in medicine for millenia. However, concern over the dangers of abuse led…
Role of endocannabinoids in regulating drug dependence
Abstract This review will discuss the latest knowledge of how the endocannabinoid system might be involved in treating addiction to…
Marijuana Dependence and Its Treatment
Abstract The prevalence of marijuana abuse and dependence disorders has been increasing among adults and adolescents in the United States.…
Pathogenic role of cardiac mast cell activation/degranulation, TNF-α, and cell death in acute drug-related fatalities
Abstract Background: Intravenous injection of narcotic stimulants affects many cellular functions relevant for the pathophysiological mechanisms of heart failure. There…
Cannabinoids: A New Group of Agonists of PPARs
Abstract Cannabinoids have been used medicinally and recreationally for thousands of years and their effects were proposed to occur mainly…
Genetic Dissection of Behavioural and Autonomic Effects of Δ9-Tetrahydrocannabinol in Mice
Abstract Marijuana and its main psychotropic ingredient Δ9-tetrahydrocannabinol (THC) exert a plethora of psychoactive effects through the activation of the…
Actions of N-arachidonyl-glycine in a rat inflammatory pain model
Abstract Background: While cannabinoid receptor agonists have analgesic activity in inflammatory pain states they produce a range of side effects.…