The endocannabinoid system in anxiety, fear memory and habituation
Abstract Evidence for the involvement of the endocannabinoid system (ECS) in anxiety and fear has been accumulated, providing leads for…
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The Soviet doctor and the treatment of drug addiction: “A difficult and most ungracious task”
Abstract This paper reviews the development of early Soviet drug treatment approaches by focusing on the struggle for disciplinary power…
The association between delusional-like experiences, and tobacco, alcohol or cannabis use: a nationwide population-based survey
Abstract Background: Previous population-based studies have found that delusional-like experiences (DLE) are prevalent in the community, and are associated with…
Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
Abstract Enteric glial cells (EGC) actively mediate acute and chronic inflammation in the gut; EGC proliferate and release neurotrophins, growth…
Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
Abstract Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to be involved in the etiology of pathological features of Alzheimer’s disease…
Medical marijuana: Medical necessity versus political agenda
Abstract Marijuana is classified by the Drug Enforcement Agency (DEA) as an illegal Schedule I drug which has no accepted…
Endocannabinoid Regulation of Acute and Protracted Nicotine Withdrawal: Effect of FAAH Inhibition
Abstract Evidence shows that the endocannabinoid system modulates the addictive properties of nicotine. In the present study, we hypothesized that…
Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones
Abstract Background: In early pregnancy, increased plasma levels of the endocannabinoid anandamide (AEA) are associated with miscarriage through mechanisms that…
Relevance of Stress and Female Sex Hormones for Emotion and Cognition
Abstract There are clear sex differences in incidence and onset of stress-related and other psychiatric disorders in humans. Yet, rodent…
Decreased Spontaneous Eye Blink Rates in Chronic Cannabis Users: Evidence for Striatal Cannabinoid-Dopamine Interactions
Abstract Chronic cannabis use has been shown to block long-term depression of GABA-glutamate synapses in the striatum, which is likely…