Clinical significance of P-class pumps in cancer
Abstract P-class pumps are specific ion transporters involved in maintaining intracellular/extracellular ion homeostasis, gene transcription, and cell proliferation and migration…
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Consideration of sex as a biological variable in the translation of pharmacotherapy for stress-associated drug seeking
Abstract Stress is a frequent precipitant of relapse to drug use. Pharmacotherapies targeting a diverse array of neural systems have…
The enhanced bioavailability of free curcumin and bioactive-metabolite tetrahydrocurcumin from a dispersible, oleoresin-based turmeric formulation
Abstract Background: Curcuminoids have been widely studied for human health and disease applications, yet bioavailability remains a hurdle to actualizing…
Use of waterpipes and other substances in adolescents: Prevalence and potential associations with mental and behavioral well-being, a cross-sectional study
Abstract INTRODUCTION: This study assess the prevalence and potential determinants (attitudes, behavioral and emotional conditions) associated with waterpipe tobacco smoking…
Cannabidiol Produces Distinct U-Shaped Dose-Response Effects on Cocaine-Induced Conditioned Place Preference and Associated Recruitment of Prelimbic Neurons in Male Rats
Abstract Background: Cannabidiol (CBD) has received attention for the treatment of substance use disorders. In preclinical models of relapse, CBD…
Solubility, thermal and photoluminescence properties of triphenyl imidazole-containing polyimides†
Abstract In this paper, three kinds of triphenyl imidazole-containing diamines including 2-phenyl-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (PBAI), 2-(4-methylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethyl phenoxy)phenyl)imidazole (MPBAI) and 2-(4-trifluoromethylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (TFPBAI) were…
Cannabidiol prevents lipopolysaccharide-induced sickness behavior and alters cytokine and neurotrophic factor levels in the brain
Abstract Background: Major depressive disorder (MDD) affects millions of people worldwide. While the exact pathogenesis is yet to be elucidated,…
Divergent evolution toward sex chromosome-specific gene regulation in Drosophila
Abstract In this study, Villa et al. compared the targeting mechanisms of the dosage compensation complex in two Drosophila species,…
Profile and Management of Toxicity of Selinexor and Belantamab Mafodotin for the Treatment of Triple Class Refractory Multiple Myeloma
Abstract Treatment options are limited for multiple myeloma patients who have developed four/five drug-refractory disease. Selinexor (Sel) and belantamab mafodotin…
Do PGY-1 residents in Emergency Medicine have enough experiences in resuscitations and other clinical procedures to meet the requirements of a Competence by Design curriculum?
Abstract Background: With the transition to a Competence by Design (CBD) curriculum, Fellow of the Royal College of Physicians in…