Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Abstract Significance Statement: Glutamate receptors play important roles in virtually all aspects of brain function and are either involved in…
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Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy
Abstract Background and Purpose: Cannabis has been used to treat epilepsy for millennia, with such use validated by regulatory approval…
An Integrative Pan-Cancer Analysis of the Prognostic and Immunological Role of Casein Kinase 2 Alpha Protein 1 (CSNK2A1) in Human Cancers: A Study Based on Bioinformatics and Immunohistochemical Analysis
Abstract Background: Although emerging animal- or cell-based evidence supports the relationship between casein kinase 2 alpha protein 1 (CSNK2A1) and…
The spliceosome pathway activity correlates with reduced anti-tumor immunity and immunotherapy response, and unfavorable clinical outcomes in pan-cancer
Keywords: Spliceosome pathway, Pan-cancer, Anti-tumor immunity, Cancer immunotherapy, Drug response, Genomic instability Authors: Zuobing Chen, Canping Chen, Lin Li, Tianfang…
Structural mapping techniques distinguish the surfaces of fibrillar 1N3R and 1N4R human tau
Abstract The rigid core of intracellular tau filaments from Alzheimer’s disease (AD), Pick’s disease (PiD), and Corticobasal disease (CBD) brains…
New Psychoactive and Classic Substances in Pooled Urine Samples Collected at The Ultra Europe Festival in Split, Croatia
Abstract We believe that analysing pooled urine samples for recreational drugs used at mass events can provide useful information about…
Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer’s Disease
Abstract Insomnia is a pervasive sleep disorder affecting numerous patients across diverse demographical populations and comorbid disease states. Contributing factors…
Features of primary pancreatic lymphoma: A bi-institutional review with an emphasis on typical and atypical imaging features
Abstract BACKGROUND: Primary pancreatic lymphoma (PPL) is a rare neoplasm. Being able to distinguish it from other pancreatic malignancies such…
Bioinformatics Analyses Reveal the Prognostic Value and Biological Roles of SEPHS2 in Various Cancers
Abstract Purpose: Selenophosphate synthetase 2 (SEPHS2) has been shown to regulate selenoprotein biosynthesis by catalyzing the synthesis of active selenium…
Financial Burden of Drugs Prescribed for Cancer-Associated Symptoms
Abstract METHODS: We reviewed relevant guidelines and compiled drugs used to manage seven cancer-associated symptoms (anorexia and cachexia, chemotherapy-induced peripheral…