The DNA damage repair-related gene PKMYT1 is a potential biomarker in various malignancies
Abstract Background: Protein kinase membrane associated tyrosine/threonine 1 (PKMYT1) regulates cell cycle and is a part of DNA damage repair…
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Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions
Abstract SIGNIFICANCE STATEMENT: Major cannabinoids and their metabolites found in the plasma of cannabis users inhibit several P450 enzymes, including…
Self-reported changes in cannabis vaping among US adolescents and young adults early in the COVID-19 pandemic
Abstract Cannabis vaping may increase susceptibility to COVID-19 infection and related outcomes; however, little is known about the impact of…
Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study
Abstract Introduction Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by chronic motor and vocal tics. While consistently effective…
Declining Inpatient Mortality Despite Increasing Thirty-Day Readmissions of Alcoholic Hepatitis in the United States From 2010 to 2018
Abstract Background: Alcoholic hepatitis (AH) readmissions are commonly secondary to relapse to alcohol use after discharge from the hospital. Methods:…
A Reason to Rethink Fasting Guidelines? Marijuana-Induced Gastroparesis and the Implications for Aspiration Risk in the Nil Per Os (NPO) Patient: A Case Report
Abstract Objective: Unusual clinical course Background: Tetrahydrocannabinol has been implicated in gastroparesis development, a disorder characterized by delayed gastric emptying…
Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series
Abstract Background: Chemotherapy-induced peripheral neuropathy is a common and often severe side effect from many chemotherapeutic agents, with limited treatment…
Endoscopic management of difficult common bile duct stones: Where are we now? A comprehensive review
Abstract Endoscopic management for difficult common bile duct (CBD) stones still presents a challenge for several reasons, including anatomic anomalies,…
Changes in gene-gene interactions associated with cancer onset and progression are largely independent of changes in gene expression
Abstract Recent findings indicate that changes underlying cancer onset and progression are not only attributable to changes in DNA structure…
Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis
Abstract Background: Chronic neuropathic pain (NP) presents therapeutic challenges. Interest in the use of cannabis-based medications has outpaced the knowledge…