MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control
Abstract Despite the clinical availability of over 30 antiseizure medications, around 30% of people with epilepsy do not achieve seizure…
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Cannabis use among workers with work-related injuries and illnesses: results from a cross-sectional study of workers’ compensation claimants in Ontario, Canada
Abstract Objectives: Little is known about how workers use cannabis following a work-related injury/illness, including whether they receive clinical guidance.…
Caregivers’ Perspectives on the Impact of Cannabidiol (CBD) Treatment for Dravet and Lennox-Gastaut Syndromes: A Multinational Qualitative Study
Abstract Objective: To increase understanding of the impact of cannabidiol (CBD) on outcomes beyond seizure control among individuals with Dravet…
Tianeptine, an Antidepressant with Opioid Agonist Effects: Pharmacology and Abuse Potential, a Narrative Review
Abstract Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US.…
CCL5 might be a prognostic biomarker and associated with immuno-therapeutic efficacy in cancers: A pan-cancer analysis
Abstract Purpose: Chemokine ligand 5 (CCL5), a vital member of the CC chemokine family, plays diverse roles in tumorigenesis, metastasis,…
A pharmacist-led community-based survey study: Determining the impact of the Covid-19 pandemic on actionable factors associated with worse cancer outcomes and cancer health disparities
Abstract Purpose: The goals of this cross-sectional community-based survey study were to assess the impact of the Covid-19 pandemic on…
Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression
Abstract Mitochondria play important roles in angiogenesis. However, the mechanisms remain elusive. In this study, we found that mitochondrial ubiquinol-cytochrome…
Chronic Pain, Cannabis Legalization and Cannabis Use Disorder in Veterans Health Administration Patients, 2005 to 2019
Abstract Background: The risk for cannabis use disorder (CUD) is elevated among U.S. adults with chronic pain, and CUD rates…
An interpretable deep learning framework for genome-informed precision oncology
Abstract Cancers result from aberrations in cellular signaling systems, typically resulting from driver somatic genome alterations (SGAs) in individual tumors.…
Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH
Abstract Numerous spider venom-derived gating modifier toxins exhibit conformational heterogeneity during purification by reversed-phase high-performance liquid chromatography (RP-HPLC). This conformational…