HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review)
Abstract Helicase POLQ-like (HELQ or Hel308), is a highly conserved, 3′-5′ superfamily II DNA helicase that contributes to diverse DNA…
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The impact of recreational cannabis laws on cannabis use disorder during “treat and release” visits to hospital emergency departments in four U.S. states, 2017–2020
Abstract States’ legalization of cannabis influences cannabis use and may increase cannabis use disorder (CUD)—a problematic pattern of use leading…
Identification of TMEM178 as a Potential Prognostic Biomarker and Therapeutic Target for Breast Cancer
Abstract Background: The transmembrane protein (TMEM) family plays important roles in cancer. However, the expression pattern and biological roles of…
Cannabidiol as an Alternative Analgesic for Acute Dental Pain
Abstract Odontogenic pain can be debilitating, and nonopioid analgesic options are limited. This randomized placebo-controlled clinical trial aimed to assess…
Role of Kinetochore Scaffold 1 (KNL1) in Tumorigenesis and Tumor Immune Microenvironment in Pan-Cancer: Bioinformatics Analyses and Validation of Expression
Abstract Purpose: Kinetochore scaffold 1 (KNL1), a crucial protein during cell mitosis participating in cell division, was widely expressed in…
Opium Effects on Pancreatobiliary System in Opium Abusers Evaluated by Endoscopic Ultrasonography
Abstract Background: Opium use is a significant social and public health issue. There are numerous effects of opium documented as…
Colloidal aggregation confounds cell-based Covid-19 antiviral screens
Abstract Colloidal aggregation is one of the largest contributors to false-positives in early drug discovery and chemical biology. Much work…
Long-term efficacy and adverse effects of cannabidiol in adjuvant treatment of drug-resistant epilepsy: a systematic review and meta-analysis
Abstract Background: Epilepsy is one of the most common chronic brain diseases. Almost one-third of patients have drug-resistant epilepsy (DRE).…
Polysubstance use in inflammatory bowel disease is associated with increased risk of emergency department visits: a longitudinal study
Abstract Background: Polysubstance use (PSU), the simultaneous use of 2 or more substances of abuse, is common in inflammatory bowel…
Anorexia of aging: An international assessment of healthcare providers’ knowledge and practice gaps
Abstract Background: Anorexia of aging is a common geriatric syndrome that includes loss of appetite and/or reduced food intake, with…