Patients’ perspectives on marijuana use for inflammatory bowel disease: a multicenter survey
Abstract Background: As marijuana use is rising among patients with inflammatory bowel disease (IBD), so is interest in its potential…
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The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis
Abstract Previous studies have determined that aberrant expression of the fas-associated death domain (FADD) contributes to the development of cancer.…
Pharmacotherapy for Dravet Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Abstract Background: Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy characterized by drug-resistant, lifelong seizures. The management of…
Pan-Cancer Analysis of Oncogenic Role of RAD54L and Experimental Validation in Hepatocellular Carcinoma
Abstract Background: RAD54L is a prominent member of the SWI2/SNF2 protein family, primarily involved in the homologous recombination repair (HRR)…
A comparative analysis of graduate preparedness for a career in General Internal Medicine before and after national subspecialty recognition to inform curricular changes: have we met the mark?
Abstract Background: A survey of General Internal Medicine (GIM) graduates published in 2006 revealed large training gaps that informed the…
Association between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals
Abstract Background: The association between cannabis use and positive symptoms in schizophrenia spectrum disorders is well documented, especially via meta-analyses.…
Cannabis Use: A New Risk Behaviour Among Adults With Congenital Heart Disease
Abstract Background: Cannabis use has increased in Canada and can be associated with adverse cardiovascular events. Given increased use and…
Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions
Abstract Oral cancer is one of the leading causes of death worldwide. Oral precancerous lesions (OPL) are the precursors of…
Nuclear mitochondria-related genes-based molecular classification and prognostic signature reveal immune landscape, somatic mutation, and prognosis for glioma
Abstract Background: Glioma is the most frequent malignant primary brain tumor, and mitochondria may influence the progression of glioma. The…
Recapitulation of patient-specific 3D chromatin conformation using machine learning
Abstract Regulatory networks containing enhancer-gene edges define cellular states. Multiple efforts have revealed these networks for reference tissues and cell…