The Role of Medicinal Cannabis as an Emerging Therapy for Opioid Use Disorder
Abstract This narrative review explores current insights into the potential use of medicinal cannabis-related products as an emerging therapy for…
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The CB1 negative allosteric modulator PSNCBAM-1 reduces ethanol self-administration via a nonspecific hypophagic effect
Abstract Alcohol use disorder (AUD) affects >15 million people in the United States. Current pharmacotherapeutic treatments for AUD are only…
A Study of Pupil Response to Light as a Digital Biomarker of Recent Cannabis Use
Abstract Introduction: Given the traffic safety and occupational injury prevention implications associated with cannabis impairment, there is a need for…
LINC00115 aggravates thyroid cancer progression by targeting miR-489-3p, which downregulates EVA1A to regulate the Hippo signaling pathway
Abstract LINC00115 has been documented to regulate many different cancers; however, its function in thyroid cancer (THCA) remains unexplored. Therefore,…
Pan-cancer prognostic model and immune microenvironment analysis of natural killer cell-related genes
Abstract Background: Natural killer (NK) cells play a significant role in antitumor immunity and are closely related to tumor prognosis…
Alzheimer’s disease drug development pipeline: 2024
Keywords: Alzheimer’s disease, amyloid, biomarkers, clinical trials, Common Alzheimer’s Disease Research Ontology (CADRO), drug development, inflammation, pharmaceutical companies, repurposed drugs,…
Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels
Abstract HCN4 channels play an important role in cardiac action potential initiation in the sinoatrial node. In this study, Page…
Cannabichromene from full-spectrum hemp extract exerts acute anti-seizure effects through allosteric activation of GABAA receptors
Abstract The approval of Epidiolex, an anti-epileptic drug containing cannabidiol (CBD) as its active component, has brought hope to patients…
Comprehensive pan-cancer analysis: essential role of ABCB family genes in cancer
Abstract Background: The adenosine triphosphate-binding-cassette (ABC) transporter orchestrates the transmembrane transport of diverse substrates with the aid of ATP as…
ALDH2 as an immunological and prognostic biomarker: Insights from pan-cancer analysis
Abstract Aldehyde dehydrogenase 2 (ALDH2) plays a critical role in safeguarding cells against acetaldehyde toxicity and is closely linked to…