Presynaptic nanoscale components of retrograde synaptic signaling
Abstract While our understanding of the nanoscale architecture of anterograde synaptic transmission is rapidly expanding, the qualitative and quantitative molecular…
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Biobased Composites from Eugenol- and Coumarin-Derived Methacrylic Latex and Hemp Nanocellulose: Cross-Linking via [2 + 2] Photocycloaddition and Barrier Properties
Abstract A novel-biobased latex was synthesized by redox-initiated emulsion copolymerization of ethoxy dihydroeugenyl methacrylate with 5 wt % of a…
Interactions between LAMP3+ dendritic cells and T-cell subpopulations promote immune evasion in papillary thyroid carcinoma
Abstract Background: The incidence of papillary thyroid cancer (PTC) continues to rise all over the world, 10–15% of the patients…
Layer specific regulation of critical period timing and maturation of mouse visual cortex by endocannabinoids
Abstract Plasticity during the critical period is important for the functional maturation of cortical neurons. While characteristics of plasticity are…
Radiologist preferences for faculty development initiatives to improve resident feedback in the era of competency-based medical education
Abstract Introduction: Since 2022, all Canadian post-graduate medical programs have transitioned to a Competence by Design (CBD) model within a…
Tandem Mass Tag-10plex (TMT-10plex) phosphoproteomics dataset for comprehensive analysis of active compounds with tyrosine kinase inhibition activity
Abstract Bioactive compounds derived from natural products demonstrate a wide range of beneficial properties in cancer treatment. One popular approach…
Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons
Abstract The authors use high-content calcium imaging and patch clamp recordings to demonstrate broad inhibition by cannabidiol of multiple receptors,…
RPN1: a pan-cancer biomarker and disulfidptosis regulator
Abstract Background: Elevated expression of SLC7A11, in conjunction with glucose deprivation, has revealed disulfidptosis as an emerging cell death modality.…
Human metabolism of the semi‐synthetic cannabinoids hexahydrocannabinol, hexahydrocannabiphorol and their acetates using hepatocytes and urine samples
Abstract Hexahydrocannabinol (HHC), hexahydrocannabiphorol (HHCP) and their acetates, HHC‐O and HHCP‐O, respectively, are emerging in Europe as alternatives to tetrahydrocannabinol…
CD112 is an epithelial-to-mesenchymal transition-related and immunological biomarker in pan-cancer
Abstract Background: The nectin adhesion molecule CD112, an important component of tumor progression, belongs to the nectin family. However, a…