Pan‑cancer analysis on the role of KMT2C expression in tumor progression and immunotherapy
Abstract Histone lysine N-methyltransferase 2C (KMT2C) is involved in transcriptional regulation and DNA damage repair. Mutations in KMT2C have been…
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Competency-Based Cardiology Training: A Simple Approach to Improve Supervisor Completion of Entrustable Professional Activities
Abstract Background: Adult cardiology residency programs formally transitioned to Competency by Design (CBD) in July 2021. CBD was designed to…
Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity
Abstract Cortical pathology involving inflammatory and neurodegenerative mechanisms is a hallmark of multiple sclerosis and a correlate of disease progression…
Posaconazole-hemp seed oil loaded nanomicelles for invasive fungal disease
Abstract Invasive fungal infections (IFI) pose a significant health burden, leading to high morbidity, mortality, and treatment costs. This study…
Overview of global monitoring systems for the side effects and adverse events associated with medicinal cannabis use: a scoping review using a systematic approach
Abstract Abstract: Objectives: The use of cannabis-based medicine (CBM) as a therapeutic has surged in Australia over the past 5…
Integrative Pan-Cancer Analysis Reveals the Oncogenic Role of MND1 and Validation of MND1’s Role in Breast Cancer
Abstract Purpose: Meiotic nuclear division 1 (MND1) is a meiosis-specific protein that promotes lung adenocarcinoma progression. However, its expression and…
Cannabinoid Awareness, Reporting Use to Health Care Providers, and Perceptions Regarding Safety – Pennsylvania, March 2023–April 2023
Abstract Introduction: With the continued societal and policy interest in cannabinoids, the Penn State Harrisburg Center for Survey Research (CSR)…
Consensus panel recommendations for the optimization of EPIDIOLEX® treatment for seizures associated with Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex
Abstract Plain language summary: Epidiolex® (cannabidiol) is approved for treating seizures in Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex.…
Effects of cannabinoid receptor activation on Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells in vitro
Abstract Purpose: Periodontitis is an inflammatory disease that results in the loss of periodontal tissue. The endocannabinoid system has anti-inflammatory…
Promoting diversity in clinical trials: insights from planning the ALUMNI AD study in historically underrepresented US populations with early symptomatic Alzheimer’s disease
Abstract Clinical trial participation across disease areas, including Alzheimer’s disease (AD), has been biased towards White participants of European ancestry.…