Young lung cancer: from diagnosis to survivorship
Abstract Background: Young patients with lung cancer represent a distinct population, with unique disease and treatment-related characteristics, as well as…
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Cannabidiol (CBD) and Colorectal Tumorigenesis: Potential Dual Modulatory Roles via the Serotonergic Pathway
Abstract Since hemp-derived cannabidiol products with less than 0.3% tetrahydrocannabinol became legal in 2018 in the United States, public interest…
Risk Factors for Common Bile Duct Stones in Patients with Previous Cholecystectomy: A Multicenter Prospective Proof-of-Concept Study
Abstract Objectives: Most studies assess risk factors for common bile duct (CBD) stones in patients with gallbladder in situ. We…
Synthetic cannabinoids in e‐cigarettes seized from English schools
Abstract Background and aims: People who use synthetic cannabinoids (SCs) report debilitating side effects and withdrawal symptoms, coupled with dependence.…
Exogenous Administration of Delta-9-Tetrahydrocannabinol Affects Adult Hippocampal Neurotransmission in Female Wistar Rats
Abstract Delta-9-tetrahydrocannabinol (THC) is a psychoactive element of Cannabis sativa and affects the human cannabinoid system through its receptors, CB1R…
Distinct Interactions of Cannabinol and Its Cytochrome P450-Generated Metabolites with Receptors and Sensory Neurons
Abstract Interest in nonpsychotropic cannabinoids like cannabinol (CBN) is increasing for pain therapy. This study delivers critical insights into CBN’s…
Synthesis, Characterization, Biological Evaluation, DFT Calculations, and Molecular Docking Study of Transition Metal Complexes Derived From a Schiff Base Ligand
Abstract The escalating global challenge of antibiotic resistance amid rising oxidative stress emphasizes the critical necessity for innovative antimicrobial strategies.…
PCNA in Pan-Cancer: A Prognostic Biomarker Unveiled Through a Data-Driven, Multidimensional Analysis of Transcriptomics, Immunity, and Functional Profiling
Abstract Proliferating cell nuclear antigen (PCNA) is a central regulator of numerous cellular processes impacting DNA metabolism and genetic integrity,…
Lifespan investigation of brain volumetric changes associated with substance use disorders
Abstract Substance use disorder (SUD) stands as a critical public health concern, contributing to substantial morbidity, mortality and societal costs.…
Target Mapping in Cancer: Ligandable Protein Pockets on 3D OncoPPI Networks
Abstract Background/Objectives: Studying protein–protein interaction (PPI) networks is crucial in understanding cancer phenotypes and molecular mechanisms. Here, we focus on…