The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer
Abstract The primary drawbacks of current cancer therapies are lower selectivity for cancer cells, more side effects, and obscure resistance…
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Cannabis use in Patients With Inflammatory Bowel Disease is Associated With Longer Endoscopic Duration and Endoscopic Inflammation
Abstract Background: Patients with inflammatory bowel disease (IBD) often experience symptoms refractory to available treatments, prompting the use of alternative…
Polysubstance Use and Social Sequelae in Women of Reproductive Age with Recent Marijuana Use
Abstract Polysubstance use (PSU) involving marijuana among women of reproductive age (WRA) is linked to psychosocial harm, yet research on…
Orally consumed cannabinoids: the effect of carrier oil on acute tissue distribution in male C57BL/6 mice
Abstract Background: Fundamental gaps in knowledge exist in understanding the tissue distribution of cannabinoids, cannabidiol (CBD) and tetrahydrocannabinol (THC), following…
Revisiting the Gateway Drug Hypothesis for Cannabis: A Secondary Analysis of a Nationwide Survey Among Community Users in Japan
Abstract Aim: Cannabis has historically been used for medicinal and industrial purposes, but is strictly regulated worldwide due to the…
Inflammatory state moderates response to cannabis on negative affect and sleep quality in individuals with anxiety
Abstract Introduction: Inflammation has been implicated as an underlying pathology in negative affect and sleep disruption. Cannabinoids like delta-9-tetrahydrocannabinol (THC)…
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Abstract A central process contributing to the phenotype of aging is cellular senescence. We recently identified the FOXO4 – p53…
The impact of self-efficacy on substance use in nursing students: the mediating role of sense of coherence
Abstract Background: Substance use among university students, particularly nursing students, poses significant health and professional risks. Alcohol and psychoactive substance…
KSHV reprograms host RNA splicing via FAM50A to activate STAT3 and drive oncogenic cellular transformation
Abstract IMPORTANCE: Kaposi’s sarcoma-associated herpesvirus (KSHV) causes cancers such as Kaposi’s sarcoma, particularly in AIDS patients. This study uncovers how…
Child and Adolescent Suicide in the Broader Area of Athens, Greece: A 13-Year Retrospective Forensic Case-Series Analysis
Abstract Purpose: Suicide is a leading cause of death among children and adolescents worldwide. This study examined the prevalence and…