Assessing the experience of using synthetic cannabinoids by means of interpretative phenomenological analysis
Abstract Background: New psychoactive substances (NPS) have been increasingly consumed by people who use drugs in recent years, which pose…
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In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease
Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is affecting an increasing number of people. It is characterized…
Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target
Abstract As a consequence of an increasingly aging population, the number of people affected by neurodegenerative disorders, such as Alzheimer’s…
Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids
Abstract Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and…
Cost of shingles: population based burden of disease analysis of herpes zoster and postherpetic neuralgia
Abstract Background: Around 30% of the population will experience herpes zoster (HZ), 10% of whom develop postherpetic neuralgia (PHN). Together,…
Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease
Abstract The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors together with the discovery of their…
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Abstract The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases.…
Medical treatment of dystonia
Abstract Therapeutic strategies in dystonia have evolved considerably in the past few decades. Three major treatment modalities include oral medications,…
Bidirectional Effects of Cannabidiol on Contextual Fear Memory Extinction
Abstract Cannabidiol (CBD) has been established to have both acute and long-lasting effects to reduce fear memory expression. The long-lasting…
Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
Abstract Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency…