An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
Abstract Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a…
Free
Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research
Abstract Much of our knowledge of the endocannabinoid system in schizophrenia comes from behavioral measures in rodents, like prepulse inhibition…
Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats
Abstract Background: Pain involves different brain regions and is critically determined by emotional processing. Among other areas, the rostral anterior…
Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice
Abstract Chronic cannabinoid consumption is an increasingly common behavior among teenagers and has been shown to cause long-lasting neurobehavioral alterations.…
Microglial Activation in the Pathogenesis of Huntington’s Disease
Abstract Huntington’s disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by expanded CAG trinucleotide repeats (>36) in exon…
Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties
Abstract Essential oils of oregano are widely recognized for their antimicrobial activity, as well as their antiviral and antifungal properties.…
Explorative Placebo-Controlled Double-Blind Intervention Study with Low Doses of Inhaled Δ9-Tetrahydrocannabinol and Cannabidiol Reveals No Effect on Sweet Taste Intensity Perception and Liking in Humans
Abstract Introduction: The endocannabinoid system (ECS) plays an important role in food reward. For example, in humans, liking of palatable…
Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults
Abstract Introduction: Cannabidiol (CBD) is a nonpsychoactive constituent of whole plant cannabis that has been reported to reduce anxiety-like behaviors…
Role of N-Arachidonoyl-Serotonin (AA-5-HT) in Sleep-Wake Cycle Architecture, Sleep Homeostasis, and Neurotransmitters Regulation
Abstract The endocannabinoid system comprises several molecular entities such as endogenous ligands [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)], receptors (CB1 and…
Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years
Abstract Cannabis extracts have been used for centuries, but its main active principle ∆9-tetrahydrocannabinol (THC) was identified about 50 years…