Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges
Abstract It is well known that certain active ingredients of the plants of Cannabis genus, i.e., the “phytocannabinoids” [pCBs; e.g.,…
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Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes
Abstract Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an…
Cannabinoid Hyperemesis Syndrome: Public Health Implications and a Novel Model Treatment Guideline
Abstract Introduction: Cannabinoid hyperemesis syndrome (CHS) is an entity associated with cannabinoid overuse. CHS typically presents with cyclical vomiting, diffuse…
Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation
Abstract Cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC) have well documented immunomodulatory effects in vitro, but not following oral administration in humans.…
Microwave-Assisted Extraction of Cannabinoids in Hemp Nut Using Response Surface Methodology: Optimization and Comparative Study
Abstract Hemp nut is commonly incorporated into several food preparations; however, most countries set regulations for hemp products according to…
Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors
Abstract Use of Cannabis, the most widely used illicit drug worldwide, is associated with acute anxiety, and anxiety disorders following…
Comparative transcriptome analysis reveals potentially novel roles of Homeobox genes in adipose deposition in fat-tailed sheep
Abstract Adipose tissues are phenotypically, metabolically and functionally heterogeneous based on the sites of their deposition. Undesirable fat deposits in…
Parameters of the Endocannabinoid System as Novel Biomarkers in Sepsis and Septic Shock
Abstract Sepsis represents a dysregulated immune response to infection, with a continuum of severity progressing to septic shock. This dysregulated…
Effect of Fungal Deterioration on Physical and Mechanical Properties of Hemp and Flax Natural Fiber Composites
Abstract The development and application of bio-sourced composites have been gaining wide attention, yet their deterioration due to the growth…
The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice
Abstract The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type…