Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia
Abstract Transient receptor potential (TRP) ion channels are widely expressed in several tissues throughout the mammalian organism. Originally, TRP channel…
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Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus
Abstract Cerebellar malformations cause changes to the sleep-wake cycle, resulting in sleep disturbance. However, it is unclear how the cerebellum…
The Endocannabinoid System across Postnatal Development in Transmembrane Domain Neuregulin 1 Mutant Mice
Abstract The use of cannabis is a well-established component risk factor for schizophrenia, particularly in adolescent individuals with genetic predisposition…
Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin
Abstract Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became…
Traversing the Links between Heavy Metal Stress and Plant Signaling
Abstract Plants confront multifarious environmental stresses widely divided into abiotic and biotic stresses, of which heavy metal stress represents one…
The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents
Abstract Enhancing endogenous cannabinoid (eCB) signaling has been considered as a potential strategy for the treatment of stress-related conditions. Fatty…
Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion
Abstract Background: The transient global cerebral hypoperfusion/reperfusion achieved by induction of Bilateral Common Carotid Artery Occlusion followed by Reperfusion (BCCAO/R)…
A Systematic Review and Meta-Analysis of the In Vivo Haemodynamic Effects of Δ9-Tetrahydrocannabinol
Abstract ∆9-Tetrahydrocannabinol (THC) has complex effects on the cardiovascular system. We aimed to systematically review studies of THC and haemodynamic…
Nabiximols combined with motivational enhancement/cognitive behavioral therapy for the treatment of cannabis dependence: A pilot randomized clinical trial
Abstract Background: The current lack of pharmacological treatments for cannabis use disorder (CUD) warrants novel approaches and further investigation of…
Estrogenic Effects of the Extracts from the Chinese Yam (Dioscorea opposite Thunb.) and Its Effective Compounds in Vitro and in Vivo
Abstract Background: The aim of this study was to explore the estrogenic effects of the extracts from Chinese yam and…