Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity
Abstract Atypical cannabinoid compounds O-1602 and O-1918 are ligands for the putative cannabinoid receptors G protein-coupled receptor 55 and G…
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Synthetic Cannabinoids Influence the Invasion of Glioblastoma Cell Lines in a Cell- and Receptor-Dependent Manner
Abstract The current treatment of glioblastoma is not sufficient, since they are heterogeneous and often resistant to chemotherapy. Earlier studies…
How effective and safe is medical cannabis as a treatment of mental disorders? A systematic review
Abstract We conducted a review of systematic reviews (SRs) and randomized-controlled trials (RCTs) to analyze efficacy and safety of cannabis-based…
Lower circulating endocannabinoid levels in children with autism spectrum disorder
Abstract Background: The endocannabinoid system (ECS) is a major regulator of synaptic plasticity and neuromodulation. Alterations of the ECS have…
Adherence to Consolidated Standards of Reporting Trials (CONSORT) Guidelines for Reporting Safety Outcomes in Trials of Cannabinoids for Chronic Pain: Protocol for a Systematic Review
Abstract Background: Chronic pain affects a significant proportion of the population and presents a major challenge to clinicians and pain…
Medical cannabis patterns of use and substitution for opioids & other pharmaceutical drugs, alcohol, tobacco, and illicit substances; results from a cross-sectional survey of authorized patients
Abstract Background: A 239-question cross-sectional survey was sent out via email in January 2017 to gather comprehensive information on cannabis…
Cannabisin F from Hemp (Cannabis sativa) Seed Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia as SIRT1 Modulator
Abstract Hemp seed (Fructus cannabis) is rich in lignanamides, and initial biological screening tests showed their potential anti-inflammatory and anti-oxidative…
Age-related differences in the impact of cannabis use on the brain and cognition: a systematic review
Abstract Electronic supplementary material: The online version of this article (10.1007/s00406-019-00981-7) contains supplementary material, which is available to authorized users.…
Prospects for the Use of Cannabinoids in Oncology and Palliative Care Practice: A Review of the Evidence
Abstract There is an increased interest in the use of cannabinoids in the treatment of symptoms in cancer and palliative…
A survey of the attitudes, beliefs and knowledge about medical cannabis among primary care providers
Abstract Background: Healthcare providers play a critical role in facilitating patient access to medical cannabis. However, previous surveys suggest only…