A Mechanistic and Pathophysiological Approach for Stroke Associated with Drugs of Abuse
Abstract Drugs of abuse are associated with stroke, especially in young individuals. The major classes of drugs linked to stroke…
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Insights From Molecular Dynamics Simulations of a Number of G-Protein Coupled Receptor Targets for the Treatment of Pain and Opioid Use Disorders
Abstract Effective treatments for pain management remain elusive due to the dangerous side-effects of current gold-standard opioid analgesics, including the…
The British Columbia Healthy Connections Project: findings on socioeconomic disadvantage in early pregnancy
Abstract Background: Maternal exposure to socioeconomic disadvantage increases the risk of child injuries and subsequent child developmental and mental health…
Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis
Abstract Accumulating evidence points towards the antipsychotic potential of cannabidiol. However, the neurocognitive mechanisms underlying the antipsychotic effect of cannabidiol…
Terpenoids and Phytocannabinoids Co-Produced in Cannabis Sativa Strains Show Specific Interaction for Cell Cytotoxic Activity
Abstract Mixtures of different Cannabis sativa phytocannabinoids are more active biologically than single phytocannabinoids. However, cannabis terpenoids as potential instigators…
Combination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways
Abstract Multiple sclerosis (MS) is a chronic and disabling disorder of the central nervous system (CNS) characterized by neuroinflammation leading…
Nicotine Gateway Effects on Adolescent Substance Use
Abstract Given the rise in teenage use of electronic nicotine delivery systems (“vaping”) in congruence with the increasing numbers of…
Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome
Abstract Lifestyle is a well-known environmental factor that plays a major role in facilitating the development of metabolic syndrome or…
Joint and separate exposure to alcohol and ∆9-tetrahydrocannabinol produced distinct effects on glucose and insulin homeostasis in male rats
Abstract Cannabis and alcohol co-use is common, and the trend may increase further given the current popularity of cannabis legalization.…
In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters
Abstract APINACA (known as AKB48, N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide), an indazole carboxamide synthetic cannabinoid, has been used worldwide as a new psychoactive substance.…