Kynurenines and the Endocannabinoid System in Schizophrenia: Common Points and Potential Interactions
Abstract Schizophrenia, which affects around 1% of the world’s population, has been described as a complex set of symptoms triggered…
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2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels
Abstract Targeted delivery of therapeutic compounds to particular cell types such that they only affect the target cells is of…
Marijuana-Derived Cannabinoids Trigger a CB2/PI3K Axis of Suppression of the Innate Response to Oral Pathogens
Abstract Cannabis use is an emergent risk factor for periodontitis, a chronic bacterial-induced disease of the supporting structures of the…
Phytochemical and Ecological Analysis of Two Varieties of Hemp (Cannabis sativa L.) Grown in a Mountain Environment of Italian Alps
Abstract Hemp (Cannabis sativa L.) is a multifunctional crop that is capable of prompt environmental adaptation. In this study, a…
Cannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia
Abstract Anticancer properties of non-psychoactive cannabinoid cannabidiol (CBD) have been demonstrated on tumors of different histogenesis. Different molecular targets for…
Tetrahydrocannabinol Sensing in Complex Biofluid with Portable Raman Spectrometer Using Diatomaceous SERS Substrates
Abstract Using thin-layer chromatography in tandem with surface-enhanced Raman spectroscopy (TLC-SERS) and tetrahydrocannabinol (THC) sensing in complex biological fluids is…
Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure
Abstract Cannabinoid receptor interacting protein 1a (CRIP1a) is an important CB1 cannabinoid receptor-associated protein, first identified from a yeast two-hybrid…
Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion
Abstract Cocaine is an addictive drug that acts in brain reward areas. Recent evidence suggests that cocaine stimulates synthesis of…
Identification of Cannabis sativa L. (hemp) Retailers by Means of Multivariate Analysis of Cannabinoids
Abstract In this work, the concentration of nine cannabinoids, six neutral cannabinoids (THC, CBD, CBC, CBG, CBN and CBDV) and…
Regulatory Policies for Alcohol, other Psychoactive Substances and Addictive Behaviours: The Role of Level of Use and Potency. A Systematic Review
Abstract The object of this contribution based on a systematic review of the literature is to examine to what degree…