A Balanced Approach for Cannabidiol Use in Chronic Pain
Abstract Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa L., has gained traction as a potential treatment for intractable…
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Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18
Abstract GPR18 is an orphan G protein-coupled receptor (GPCR) expressed in cells of the immune system. It is activated by…
Long-Term Aberrations To Cerebellar Endocannabinoids Induced By Early-Life Stress
Abstract Emerging evidence points to the role of the endocannabinoid system in long-term stress-induced neural remodeling with studies on stress-induced…
Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward
Abstract Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of the World Health Organization. However,…
The Cannabinoid Receptor CB1 Stabilizes Sperm Chromatin Condensation Status During Epididymal Transit by Promoting Disulphide Bond Formation
Abstract The cannabinoid receptor CB1 regulates differentiation of spermatids. We recently characterized spermatozoa from caput epididymis of CB1-knock-out mice and…
Endocannabinoid System Components as Potential Biomarkers in Psychiatry
Abstract The high heterogeneity of psychiatric disorders leads to a lack of diagnostic precision. Therefore, the search of biomarkers is…
Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?
Abstract Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used for different purposes, like the production…
Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model
Abstract Dravet syndrome is a catastrophic epilepsy of childhood, characterized by cognitive impairment, severe seizures, and increased risk for sudden…
Visualising Silicon in Plants: Histochemistry, Silica Sculptures and Elemental Imaging
Abstract Silicon is a non-essential element for plants and is available in biota as silicic acid. Its presence has been…
Early 5‐HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse
Abstract Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed…