RNA Methylation in Cancer Metabolism: from Mechanisms to Therapeutic Opportunities
Abstract One of the most important changes in the transformation of normal cells into tumor cells is metabolism. In order…
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Pan-Cancer Analysis of Enhancer-Induced PAN3-AS1 and Experimental Validation as a WFDC13-Promoting Factor in Colon Cancer
Abstract Background: Long non-coding RNAs (lncRNAs) act as epigenetic regulators for tumor hallmarks. This investigation sought to probe the carcinogenic…
Single-cell and spatial transcriptomics reveal P4HA2-mediated radiotherapy resistance mechanisms in breast cancer
Abstract Background: Radiotherapy resistance in breast cancer remains a major clinical challenge. The key molecular determinants and cellular populations driving…
Enhancing cancer susceptibility to disulfidptosis by inducing cell cycle arrest and impairing DNA repair
Abstract Disulfidptosis—a regulated cell death caused by disulfide stress under glucose starvation and high SLC7A11—offers a potential cancer vulnerability, but…
Computational Identification of Potent Multitarget Natural Ligands for Alzheimer’s Disease Therapeutics
Abstract Alzheimer’s disease (AD), a complex neurodegenerative disorder, urgently necessitates a multitarget therapeutic approach. This study presents a novel in…
Cannabis use among primary care patients with depression and anxiety disorders: cross-sectional analysis in a large health system in Los Angeles, CA
Abstract Background: Depression, anxiety, and cannabis use are growing, interconnected primary care concerns, but remain understudied due few health systems…
Ultrasound‐Assisted Extraction Using a 3D‐Printed Device Functionalized With SPE Sorbent for UHPLC‐DAD Analysis of Pesticide Residues in Honey
Abstract The presence of pesticide residues in honey represents a significant concern for food safety and public health, underscoring the…
Enhanced machine learning and hybrid ensemble approaches for Coronary Heart Disease prediction
Abstract Coronary heart disease (CHD) remains the leading cause of mortality worldwide, disproportionately affecting low- and middle-income countries where diagnostic…
Breaking biofilm barriers in skin wounds: Membrane-Active antimicrobials in an era of resistance
Abstract Chronic wounds remain a significant challenge for healthcare systems worldwide, placing a considerable burden on both patients and resources.…
Compassion Fatigue Among Critical Care Nurses and Physicians: A Scoping Review
Abstract Introduction: The continuous engagement with critically ill patients leaves healthcare providers vulnerable to Secondary Traumatic Stress (STS), consequently developing…