System, Method and Software for Calculation of a Cannabis Drug Efficiency Index for the Reduction of Inflammation
Abstract There are many varieties of Cannabis sativa that differ from each other by composition of cannabinoids, terpenes and other…
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Mechanical and Air Permeability Performance of Novel Biobased Materials from Fungal Hyphae and Cellulose Fibers
Abstract Novel biobased materials from fungal hyphae and cellulose fibers have been proposed to address the increasing demand for natural…
Cannabinoids in Medicine: Cancer, Immunity, and Microbial Diseases
Abstract Recently, there has been a growing interest in the medical applications of Cannabis plants. They owe their unique properties…
The Role of Gamma Oscillations in the Pathophysiology of Substance Use Disorders
Abstract Substance use disorders (SUDs) are a major public health problem—with over 200 million people reporting drug use in 2016.…
Pyrrolidinyl Synthetic Cathinones α-PHP and 4F-α-PVP Metabolite Profiling Using Human Hepatocyte Incubations
Abstract For more than ten years, new synthetic cathinones (SCs) mimicking the effects of controlled cocaine-like stimulants have flooded the…
Alterations in Rat Accumbens Dopamine, Endocannabinoids and GABA Content During WIN55,212-2 Treatment: The Role of Ghrelin
Abstract The endocannabinoid/CB1R system as well as the central ghrelin signalling with its growth hormone secretagogoue receptors (GHS-R1A) are importantly…
Phenolic Compounds Cannabidiol, Curcumin and Quercetin Cause Mitochondrial Dysfunction and Suppress Acute Lymphoblastic Leukemia Cells
Abstract Anticancer activity of different phenols is documented, but underlying mechanisms remain elusive. Recently, we have shown that cannabidiol kills…
(Endo)Cannabinoids and Gynaecological Cancers
Abstract Simple Summary: Cancers of the female reproductive system are common and are responsible for a large number of deaths…
Possible Receptor Mechanisms Underlying Cannabidiol Effects on Addictive-like Behaviors in Experimental Animals
Abstract Substance use disorder (SUD) is a serious public health problem worldwide for which available treatments show limited effectiveness. Since…
In Silico and In Vitro Analysis of Major Cannabis-Derived Compounds as Fatty Acid Amide Hydrolase Inhibitors
Abstract Accumulated evidence suggests that enhancing the endocannabinoid (eCB) tone, in particular of anandamide (N-arachidonoylethanolamine, AEA), has therapeutic potential in…